专利检索 ap:("YUHAN CORPORATION" OR "INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY") AND inv:"Man Sil PARK" 第 1 页

1.

发明申请
FUSION PROTEIN COMPRISING THYROTROPIN RECEPTOR VARIANTS AND USE THEREOF 有权

公开(公告)号：US20210221869A1

公开(公告)日：2021-07-22

申请号：US17256296

申请日：2019-07-24

申请人： YUHAN CORPORATION , INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

发明人： Moo Young SONG , Taejin YOON , Jung-Sun LEE , Byung Hyun CHOI , In Hwan LIM , Man Sil PARK , Jin-Hyoung LEE , Hyoung Sig SEO , Hyeon Woo KANG , Sung Ho KIM , Eun Jig LEE , Jin Sook YOON , Cheol Ryong KU

IPC分类号： C07K14/72

摘要： Disclosed are a fusion protein comprising a thyrotropin receptor (TSHR) fragment and the use thereof. More specifically, disclosed are a fusion protein comprising a TSHR fragment comprising an extracellular domain of a wild-type TSHR and having a substitution of an amino acid at specific position and an immunoglobulin Fc region or a carboxy-terminal cap (C-CAP), and the use thereof. The fusion protein has improved pharmaceutical efficacy, in-vivo persistence and protein stability and a pharmaceutical composition containing the fusion protein as an active ingredient is useful as a therapeutic agent or diagnostic reagent for the alleviation of Graves' disease and Graves' ophthalmopathy.