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1.发明申请COMPOSITE IMPLANTS FOR PROMOTING BONE REGENERATION AND AUGMENTATION AND METHODS FOR THEIR PREPARATION AND USE 审中-公开用于促进骨髓再生和补充的复合植入物及其制备和使用方法公开(公告)号：US20090269386A1
公开(公告)日：2009-10-29
申请号：US12432830
申请日：2009-04-30
申请人： YUVAL ZUBERY , ARIE GOLDLUST , THOMAS BAYER , ERAN NIR
发明人： YUVAL ZUBERY , ARIE GOLDLUST , THOMAS BAYER , ERAN NIR
摘要： Collagen based matrices cross-linked by a reducing sugar(s) are used for preparing composite matrices, implants and scaffolds. The composite matrices may have at least two layers including reducing sugar cross-linked collagen matrices of different densities. The composite matrices may be used in bone regeneration and/or augmentation applications. Scaffolds including glycated and/or reducing sugar cross-linked collagen exhibit improved support for cell proliferation and/or growth and/or differentiation. The denser collagen matrix of the composite matrices may have a dual effect initially functioning as a cell barrier and later functioning as an ossification supporting layer. The composite matrices, implants and scaffolds may be prepared using different collagen types and collagen mixtures and by cross-linking the collagen(s) using a reducing sugar or a mixture of reducing sugars. The composite matrices, implants and scaffolds may include additives and/or living cells.
摘要翻译： 用还原糖交联的基于胶原的基质用于制备复合基质，植入物和支架。 复合基质可以具有至少两层，包括不同密度的还原糖交联的胶原基质。 复合基质可用于骨再生和/或增强应用。 包括糖基化和/或还原糖交联胶原的支架显示改善的对细胞增殖和/或生长和/或分化的支持。 复合基质的更密集的胶原基质可能具有起初作为细胞屏障起作用的双重作用，并且此后作为骨化支持层起作用。 复合基质，植入物和支架可以使用不同的胶原类型和胶原混合物和使用还原糖或还原糖的混合物交联胶原来制备。 复合基质，植入物和支架可以包括添加剂和/或活细胞。
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