公开(公告)号：US20160201131A1

公开(公告)日：2016-07-14

申请号：US14879099

申请日：2015-10-09

申请人： Yan Wang ,  Jianming Xu ,  Chun Gong

发明人： Yan Wang ,  Jianming Xu ,  Chun Gong

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/6809 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2535/122 ,  C12Q2537/165

摘要： The present invention provides a method for detecting low frequency drug resistant mutations using ultra deep amplicon sequencing. Multiple selection criteria based on biological relevance were applied to filter out low frequency background noise and lead to reliable identification of drug resistance related mutations. A method to predict the occurrence of drug resistance during the treatment is also provided.

摘要翻译： 本发明提供使用超深度扩增子测序检测低频耐药性突变的方法。 应用基于生物相关性的多种选择标准来筛选低频背景噪声，并导致耐药相关突变的可靠鉴定。 还提供了一种预测治疗期间耐药性发生的方法。