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公开(公告)号：US20140194458A1
公开(公告)日：2014-07-10
申请号：US14124570
申请日：2012-06-15
申请人： Yang Wang , Xiufeng Yan , Lijia Jing , Weimin Ding , Jian Zheng , Qiuying Pang , Tao Yu
发明人： Yang Wang , Xiufeng Yan , Lijia Jing , Weimin Ding , Jian Zheng , Qiuying Pang , Tao Yu
IPC分类号： C07D491/22
CPC分类号： C07D491/22
摘要： Provided is a 10-methoxycamptothecine derivate of formula (1), wherein R is selected from hydrogen, C1-6 alkyl, C1-6 haloalkyl, aryl substituted C1-6 alkyl, phosphate substituted C1-6 alkyl, amino-substituted C1-6 alkyl, carboxyl substituted C1-6 alkyl, hydroxyl substituted C1-6 alkyl, and amide- substituted C1-6 alkyl; R1 is selected from hydrogen and t-butoxycarbonyl substituted amino. Also provided in the present invention are the preparation method of the derivate and the use thereof in anti-tumor drug preparation.
摘要翻译： 提供式（1）的10-甲氧基喜树碱衍生物，其中R选自氢，C 1-6烷基，C 1-6卤代烷基，芳基取代的C 1-6烷基，磷酸酯取代的C 1-6烷基，氨基取代的C 1-6 烷基，羧基取代的C 1-6烷基，羟基取代的C 1-6烷基和酰胺取代的C 1-6烷基; R1选自氢和叔丁氧基羰基取代的氨基。 本发明还提供了其在抗肿瘤药物制备中的衍生及其用途的制备方法。
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公开(公告)号：US09034894B2
公开(公告)日：2015-05-19
申请号：US14124570
申请日：2012-06-15
申请人： Yang Wang , Xiufeng Yan , Lijia Jing , Weimin Ding , Jian Zheng , Qiuying Pang , Tao Yu
发明人： Yang Wang , Xiufeng Yan , Lijia Jing , Weimin Ding , Jian Zheng , Qiuying Pang , Tao Yu
IPC分类号： C07D491/22
CPC分类号： C07D491/22
摘要： Provided is a 10-methoxycamptothecine derivate of formula (1), wherein R is selected from hydrogen, C1-6 alkyl, C1-6 haloalkyl, aryl substituted C1-6 alkyl, phosphate substituted C1-6 alkyl, amino-substituted C1-6 alkyl, carboxyl substituted C1-6 alkyl, hydroxyl substituted C1-6 alkyl, and amide-substituted C1-6 alkyl; R1 is selected from hydrogen and t-butoxycarbonyl substituted amino. Also provided in the present invention are the preparation method of the derivate and the use thereof in anti-tumor drug preparation.
摘要翻译： 提供式（1）的10-甲氧基喜树碱衍生物，其中R选自氢，C 1-6烷基，C 1-6卤代烷基，芳基取代的C 1-6烷基，磷酸酯取代的C 1-6烷基，氨基取代的C 1-6 烷基，羧基取代的C 1-6烷基，羟基取代的C 1-6烷基和酰胺取代的C 1-6烷基; R1选自氢和叔丁氧基羰基取代的氨基。 本发明还提供了其在抗肿瘤药物制备中的衍生及其用途的制备方法。
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