公开(公告)号：US5387236A

公开(公告)日：1995-02-07

申请号：US988777

申请日：1992-12-10

申请人： Yasuhara Noishiki ,  Teruo Miyata

发明人： Yasuhara Noishiki ,  Teruo Miyata

IPC分类号： A61F2/06 ,  A61L27/50

CPC分类号： A61L27/507 ,  A61F2/062 ,  Y10S623/901 ,  Y10S623/921

摘要： The invention relates to a vascular prosthesis wherein, fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle cells and fibroblast cells are deposited and captured within the wall of a vascular prosthesis substrate; a manufacturing method comprising the steps of immersing a vascular prosthesis substrate into a dispersed solution of fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle cells and fibroblast cells, and depositing and capturing the cells and/or tissue fragments on the inner wall and within the wall of the vascular prosthesis from one side to the other side of the vascular prosthesis substrate wall by providing a pressure differential between the outside and the inside of the vascular prosthesis substrate; and a substrate suitable for manufacturing a vascular prosthesis having a porous membrane having pores capable of trapping tissue fragments, or a laminate structure with such a membrane and another porous membrane having pores not large enough to pass the cells or tissue fragments.

摘要翻译： 本发明涉及一种血管假体，其中沉积并俘获诸如血管组织，结缔组织，脂肪组织和构成血管壁的肌肉组织和/或细胞如血管内皮细胞，平滑肌细胞和成纤维细胞的生物组织的片段 血管假体基底的壁; 一种制造方法，包括以下步骤：将血管假体底物浸入诸如血管组织，结缔组织，脂肪组织和肌肉组织和/或组成血管壁的细胞如血管内皮细胞，平滑肌细胞的分散溶液中 和成纤维细胞，并且通过在血管假体基底壁的一侧到另一侧通过在外部和外侧之间的压力差来沉积和捕获血管假体的内壁和内壁内的细胞和/或组织碎片 血管假体底物内; 以及适于制造具有多孔膜的血管假体的基底，其具有能够捕获组织碎片的孔，或具有这种膜的层压结构和具有不足以穿过细胞或组织碎片的孔的另一多孔膜。

公开(公告)号：US5171261A

公开(公告)日：1992-12-15

申请号：US508618

申请日：1990-04-13

申请人： Yasuhara Noishiki ,  Teruo Miyata

发明人： Yasuhara Noishiki ,  Teruo Miyata

IPC分类号： A61F2/06 ,  A61L27/50

CPC分类号： A61L27/507 ,  A61F2/062 ,  Y10S623/901 ,  Y10S623/921

摘要： The invention relates to a vascular prosthesis wherein, fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle cells and fibroblast cells are deposited and captured within the wall of a vascular prosthesis substrate; a manufacturing method comprising the steps of immersing a vascular prosthesis substrate into a dispersed solution of fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle cells and fibroblast cells, and depositing and capturing the cells and/or tissue fragments on the inner wall and within the wall of the vascular prosthesis from one side to the other side of the vascular prosthesis substrate wall by providing a pressure differential between the outside and the inside of the vascular prosthesis substrate; and a substrate suitable for manufacturing a vascular prosthesis having a porous membrane having pores capable of trapping tissue fragments, or a laminate structure with such a membrane and another porous membrane having pores not large enough to pass the cells or tissue fragments.