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    Fused pyrimidine derivative, process for preparation of same and pharmaceutical preparation comprising same as active ingredient
    1.
    发明授权
    Fused pyrimidine derivative, process for preparation of same and pharmaceutical preparation comprising same as active ingredient 失效
    熔融嘧啶衍生物，其制备方法和包含与活性成分相同的药物制剂

    公开(公告)号：US5378700A

    公开(公告)日：1995-01-03

    申请号：US839769

    申请日：1992-06-09

    申请人： Yasuji Sakuma ,  Masaichi Hasegawa ,  Kenichiro Kataoka ,  Kenji Hoshina ,  Noboru Yamazaki ,  Takashi Kadota ,  Hisao Yamaguchi

    发明人： Yasuji Sakuma ,  Masaichi Hasegawa ,  Kenichiro Kataoka ,  Kenji Hoshina ,  Noboru Yamazaki ,  Takashi Kadota ,  Hisao Yamaguchi

    IPC分类号： A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  C07D471/04 ,  C07D487/04

    CPC分类号： C07D471/04 ,  C07D487/04

    摘要： Disclosed is a fused pyrimidine of the formula [I] ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are as defined in the specification, Y represents a linking group of the formula ##STR2## wherein n is an integer of from 4 to 6, ##STR3## wherein A is a hydrogen atom or alkyl group; and Z represents a hydrogen atom, or other substituents; or Y and Z together represent an unsubstituted or substituted alkyl, alkenyl or arylalkyl group; or a 5- to 7-member heterocyclic ring which has a nitrogen atom, and further, an oxygen or sulfur atom as a hetero atom other than the nitrogen atom, being bonded via the nitrogen atom therein to the 4-position of the pyrimidine ring of the formula (I), a 5- to 7-member unsaturated heterocyclic ring which has 1 to 3 nitrogen atoms being bonded via the nitrogen atom therein to the 4-position of the pyrimidine ring of the formula (I), or a fused biheterocyclic ring constructed with 5- or 6-membered aromatic or non-aromatic rings, which has 1 to 3 nitrogen atoms in any position, being bonded via the nitrogen atom therein to the 4-position of the pyrimidine ring of the formula (I); andm is an integer of from 1 to 3;and a pharmaceutically acceptable acid addition salt thereof, as well as a process for producing same and a pharmaceutical preparation useful for a treatment of hypoxemia associated with respiratory diseases.

    摘要翻译： PCT No.PCT / JP90 / 01313 Sec。 371日期：1992年6月9日 102（e）日期1992年6月9日PCT提交1990年10月11日PCT公布。 出版物WO91 / 05784 日期：1991年5月2日。公开是式[I]的融合嘧啶其中R 1，R 2和R 3如说明书中所定义，Y表示式的连接基团，其中n 是4至6的整数，其中A是氢原子或烷基; O（S） Z表示氢原子或其它取代基; 或Y和Z一起表示未取代或取代的烷基，烯基或芳基烷基; 或具有氮原子的5-至7-元杂环，以及作为氮原子以外的杂原子的氧或硫原子通过氮原子键合到嘧啶环的4-位上 式（I）的通式（I）中的氮原子数为1〜3的5〜7元不饱和杂环与式（I）的嘧啶环的4-位连接， 在其中具有1至3个氮原子的5-或6-元芳族或非芳族环经由其中的氮原子键合到式（I）的嘧啶环的4-位上构成的双杂环， ; m为1〜3的整数， 和其药学上可接受的酸加成盐，以及其制备方法和用于治疗与呼吸系统疾病相关的低氧血症的药物制剂。

    Method for producing meal containing mannose
    3.
    发明授权
    Method for producing meal containing mannose 失效
    生产含有甘露糖的膳食的方法

    公开(公告)号：US06797292B2

    公开(公告)日：2004-09-28

    申请号：US10250452

    申请日：2003-10-31

    申请人： Futoshi Yokomizo ,  Takashi Kadota

    发明人： Futoshi Yokomizo ,  Takashi Kadota

    IPC分类号： A23K116

    CPC分类号： A23K10/14 ,  A23K10/12 ,  A23K10/37 ,  A23K20/163 ,  A23K40/00 ,  Y02P60/877

    摘要： A method for producing meal containing mannose, wherein powder particles containing cellulose and/or hemicellulose is mixed with the wet composition obtained by having a mannnan degrading enzyme function to Arecaceae plant-derived meals such as copra meal and/or palm kernel meal followed by the drying process. Production rate of mannose is increased by causing reaction under high level of water content, in addition to which drying efficiency is increased by mixing hygroscopic fiber materials to the wet composition, an enzymic reactant, and thus meal containing mannose can be produced with high efficiency and good economical performance.

    摘要翻译： 一种含有甘露糖的制备方法，其中将含有纤维素和/或半纤维素的粉末颗粒与通过具有甘露聚糖降解酶功能获得的湿组合物混合到白菜植物来源的食物如椰肉粉和/或棕榈仁粉， 干燥过程。 通过在高水平含量下引起反应，增加甘露糖的生产速率，除了通过将吸湿性纤维材料与湿组合物混合之外，干燥效率提高，酶反应物，因此可以高效率地制备含有甘露糖的膳食， 良好的经济性能。