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1.发明公开公开(公告)号：US20240076611A1
公开(公告)日：2024-03-07
申请号：US18225360
申请日：2023-07-24
申请人： Ye Yuan , Lee D. Spate , Randall S. Prather , R. Michael Roberts
发明人： Ye Yuan , Lee D. Spate , Randall S. Prather , R. Michael Roberts
IPC分类号： C12N5/075
CPC分类号： C12N5/0609 , C12N2501/10 , C12N2501/105 , C12N2501/115
摘要： The present invention provides a novel oocyte maturation medium or/and embryo culture medium with a chemically defined supplement to produce matured oocytes at high efficiency. The inventive medium or supplement comprises three growth factors, namely, fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF), and insulin-like growth factor 1 (IGF-1) in a synergistic combination. Methods for oocyte and embryo culture are also provided.
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2.发明申请公开(公告)号：US20210017490A1
公开(公告)日：2021-01-21
申请号：US16891776
申请日：2020-06-03
申请人： Ye Yuan , Lee D. Spate , Randall S. Prather , R. Michael Roberts
发明人： Ye Yuan , Lee D. Spate , Randall S. Prather , R. Michael Roberts
IPC分类号： C12N5/075
摘要： The present invention provides a novel oocyte maturation medium or/and embryo culture medium with a chemically defined supplement to produce matured oocytes at high efficiency. The inventive medium or supplement comprises three growth factors, namely, fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF), and insulin-like growth factor 1 (IGF-1) in a synergistic combination. Methods for oocyte and embryo culture are also provided.
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3.发明申请公开(公告)号：US20170258495A1
公开(公告)日：2017-09-14
申请号：US15445621
申请日：2017-02-28
申请人： Ye Yuan , Lee D. Spate , Randall S. Prather , R. Michael Roberts
发明人： Ye Yuan , Lee D. Spate , Randall S. Prather , R. Michael Roberts
IPC分类号： A61B17/435 , C12N5/075
CPC分类号： C12N5/0609 , C12N5/0604 , C12N2501/10 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/235 , C12N2501/31 , C12N2501/727 , C12N2517/04 , C12N2517/10
摘要： The present invention provides a novel oocyte maturation medium or/and embryo culture medium with a chemically defined supplement to produce matured oocytes at high efficiency. The inventive medium or supplement comprises three growth factors, namely, fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF), and insulin-like growth factor 1 (IGF-1) in a synergistic combination. Methods for oocyte and embryo culture are also provided.
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4.发明授权公开(公告)号：US11753622B2
公开(公告)日：2023-09-12
申请号：US16891776
申请日：2020-06-03
申请人： Ye Yuan , Lee D. Spate , Randall S. Prather , R. Michael Roberts
发明人： Ye Yuan , Lee D. Spate , Randall S. Prather , R. Michael Roberts
IPC分类号： C12N5/075
CPC分类号： C12N5/0609 , C12N2501/10 , C12N2501/105 , C12N2501/115
摘要： The present invention provides a novel oocyte maturation medium or/and embryo culture medium with a chemically defined supplement to produce matured oocytes at high efficiency. The inventive medium or supplement comprises three growth factors, namely, fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF), and insulin-like growth factor 1 (IGF-1) in a synergistic combination. Methods for oocyte and embryo culture are also provided.
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5.发明授权
公开(公告)号：US4997646A
公开(公告)日：1991-03-05
申请号：US312853
申请日：1989-02-23
IPC分类号： A61K38/21
CPC分类号： A61K38/212
摘要： A method for enhancing the fertility and for prolonging the lifespan of the corpus luteum in female mammals. The method comprising administering to the female mammal an effective amount of an interferon alpha together with one or more pharmaceutically acceptable excipients.
摘要翻译： 一种提高雌性哺乳动物黄体生育力和延长黄体寿命的方法。 该方法包括向雌性哺乳动物施用有效量的干扰素α以及一种或多种药学上可接受的赋形剂。
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