公开(公告)号：US20180161300A1

公开(公告)日：2018-06-14

申请号：US15571071

申请日：2016-05-10

Applicant: Yeda Research And Development Co. Ltd.

Inventor： Ayelet EREZ ,  Shiran RABINOVICH ,  Alon SILBERMAN ,  Shani AGRON

IPC: A61K31/216 ,  A61P35/00 ,  A61K31/713 ,  A61K31/513 ,  C12N15/113 ,  A61K45/06

CPC classification number: A61K31/216 ,  A61K31/198 ,  A61K31/513 ,  A61K31/713 ,  A61K45/06 ,  A61P35/00 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/531

Abstract: Provided are methods, pharmaceutical compositions and kits for treating cancer in a subject in need thereof, by administering to the subject a therapeutically effective amount of an agent which downregulates a mitochondrial aspartate-dependent pyrimidine synthesis, thereby treating the cancer.