公开(公告)号：US08999332B2

公开(公告)日：2015-04-07

申请号：US13916633

申请日：2013-06-13

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit Sagi ,  Gabriel Rosenblum

IPC: A61K39/395 ,  C12N9/64 ,  A61K38/00

CPC classification number: C07K16/40 ,  A61K38/005 ,  A61K39/3955 ,  C07K2299/00 ,  C12N9/6491 ,  C12Q1/37 ,  C12Y304/24035 ,  G01N33/573 ,  G01N2333/96494 ,  G01N2500/04 ,  G01N2500/20

Abstract: A method of regulating an activity of metalloproteinase 9 (MMP-9) is disclosed. The method comprises contacting the MMP-9 with an agent which specifically interacts with an OG domain of the MMP-9. Molecules capable of specifically interacting with the OG domain, methods of identifying same, pharmaceutical compositions comprising same and uses thereof are also disclosed.

Abstract translation: 公开了一种调节金属蛋白酶9（MMP-9）活性的方法。 该方法包括使MMP-9与与MMP-9的OG结构域特异性相互作用的试剂接触。 还可以公开能够与OG结构域特异性相互作用的分子，鉴定其的方法，包含其的药物组合物及其用途。

公开(公告)号：US20150158953A1

公开(公告)日：2015-06-11

申请号：US14624597

申请日：2015-02-18

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Irit SAGI ,  Gabriel Rosenblum

IPC: C07K16/40 ,  C12Q1/37 ,  G01N33/573

CPC classification number: C07K16/40 ,  A61K38/005 ,  A61K39/3955 ,  C07K2299/00 ,  C12N9/6491 ,  C12Q1/37 ,  C12Y304/24035 ,  G01N33/573 ,  G01N2333/96494 ,  G01N2500/04 ,  G01N2500/20

Abstract: A method of regulating an activity of metalloproteinase 9 (MMP-9) is disclosed. The method comprises contacting the MMP-9 with an agent which specifically interacts with an OG domain of the MMP-9. Molecules capable of specifically interacting with the OG domain, methods of identifying same, pharmaceutical compositions comprising same and uses thereof are also disclosed.

Abstract translation: 公开了一种调节金属蛋白酶9（MMP-9）活性的方法。 该方法包括使MMP-9与与MMP-9的OG结构域特异性相互作用的试剂接触。 还可以公开能够与OG结构域特异性相互作用的分子，鉴定其的方法，包含其的药物组合物及其用途。

公开(公告)号：US20130280247A1

公开(公告)日：2013-10-24

申请号：US13916633

申请日：2013-06-13

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Irit SAGI ,  Gabriel Rosenblum

IPC: A61K39/395 ,  A61K38/00

CPC classification number: C07K16/40 ,  A61K38/005 ,  A61K39/3955 ,  C07K2299/00 ,  C12N9/6491 ,  C12Q1/37 ,  C12Y304/24035 ,  G01N33/573 ,  G01N2333/96494 ,  G01N2500/04 ,  G01N2500/20

Abstract: A method of regulating an activity of metalloproteinase 9 (MMP-9) is disclosed. The method comprises contacting the MMP-9 with an agent which specifically interacts with an OG domain of the MMP-9. Molecules capable of specifically interacting with the OG domain, methods of identifying same, pharmaceutical compositions comprising same and uses thereof are also disclosed.