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公开(公告)号：US20170306049A1
公开(公告)日：2017-10-26
申请号：US15508112
申请日：2015-09-08
Applicant: Yeda Research and Development Co., Ltd.
Inventor： Yosef YARDEN , Nadège GABORIT , Moshit LINDZEN
IPC: C07K16/32 , G01N33/574 , C07K16/30 , A61K39/00
Abstract: An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain specifically binding human HER-3 with a KD value of 10 nM or lower, wherein the polypeptide inhibits neuregulin (NRG) binding to the human HERS and NRG-induced cancer cell migration and proliferation.
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