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1.发明授权PON polypeptides, polynucleotides encoding same and compositions and methods utilizing same 有权PON多肽，编码它们的多核苷酸以及使用它们的组合物和方法公开(公告)号：US09023631B2
公开(公告)日：2015-05-05
申请号：US14058334
申请日：2013-10-21
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Dan S. Tawfik , Amir Aharoni , Leonid Gaydukov , Joel L. Sussman , Israel Silman
CPC classification number: C12N9/18 , A61K38/00 , C12N9/16 , Y02A50/473
Abstract: Isolated polynucleotides and polypeptides encoded therefrom are provided. These include mutated PON enzymes with increased, modified or substantially the same substrate specificity as compared to respective wild-type PON. Also provided are kits and methods using these enzymes.
Abstract translation: 提供了分离的多核苷酸及其编码的多肽。 这些包括与相应的野生型PON相比具有增加的，修饰的或基本上相同的底物特异性的突变的PON酶。 还提供了使用这些酶的试剂盒和方法。
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2.发明申请PON POLYPEPTIDES, POLYNUCLEOTIDES ENCODING SAME AND COMPOSITIONS AND METHODS UTILIZING SAME 有权PON多肽，编码它们的多核苷酸和组合物以及使用它们的方法公开(公告)号：US20140079682A1
公开(公告)日：2014-03-20
申请号：US14058334
申请日：2013-10-21
Applicant: Yeda Research and Development Co., Ltd.
Inventor： Dan S. TAWFIK , Amir Aharoni , Leonid Gaydukov , Joel L. Sussman , Israel Silman
IPC: C12N9/18
CPC classification number: C12N9/18 , A61K38/00 , C12N9/16 , Y02A50/473
Abstract: Isolated polynucleotides and polypeptides encoded therefrom are provided. These include mutated PON enzymes with increased, modified or substantially the same substrate specificity as compared to respective wild-type PON. Also provided are kits and methods using these enzymes.
Abstract translation: 提供了分离的多核苷酸及其编码的多肽。 这些包括与相应的野生型PON相比具有增加的，修饰的或基本上相同的底物特异性的突变的PON酶。 还提供了使用这些酶的试剂盒和方法。
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