公开(公告)号：US20240156959A1

公开(公告)日：2024-05-16

申请号：US18544514

申请日：2023-12-19

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yosef YARDEN ,  Ashish NORONHA

IPC: A61K39/395 ,  A61K31/502 ,  A61K31/506 ,  A61P35/00

CPC classification number: A61K39/3955 ,  A61K31/502 ,  A61K31/506 ,  A61P35/00

Abstract: A method of treating cancer in a subject in need thereof is disclosed wherein cancer cells of the subject express an EGFR having a mutation in a kinase domain of the receptor. The method comprises administering to the subject a therapeutically effective amount of: (i) an anti-epidermal growth factor receptor (anti-EGFR) antibody; (ii) an AXL inhibitor, and optionally (iii) a tyrosine kinase inhibitor (TKI). Also disclosed is a new anti-AXL antibody.