公开(公告)号：US20190031733A1

公开(公告)日：2019-01-31

申请号：US16055241

申请日：2018-08-06

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rachel Lea EISENBACH ,  Yosi GOZLAN ,  Esther TZEHOVAL

IPC: C07K14/705 ,  A61K35/17 ,  C12N15/10 ,  C07K14/725

Abstract: The present invention relates to methods and systems for increasing the affinity of a T cell receptor (TCR) to its ligand by subjecting the TCR gene to somatic hypermutation. The present invention further relates to use of affinity maturated TCRs to create T cells reactive against a selected antigen.

公开(公告)号：US20220211758A1

公开(公告)日：2022-07-07

申请号：US17574626

申请日：2022-01-13

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rachel Lea EISENBACH ,  Yosi GOZLAN ,  Esther TZEHOVAL

IPC: A61K35/17 ,  C07K14/725 ,  C12N15/10 ,  C12N15/63 ,  C12N15/85 ,  C12N5/0783 ,  C12N5/10 ,  C07K14/705

Abstract: The present invention relates to methods and systems for increasing the affinity of a T cell receptor (TCR) to its ligand by subjecting the TCR gene to somatic hypermutation. The present invention further relates to use of affinity maturated TCRs to create T cells reactive against a selected antigen.

公开(公告)号：US20230242611A1

公开(公告)日：2023-08-03

申请号：US18107573

申请日：2023-02-09

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rachel Lea EISENBACH ,  David BASSAN ,  Yosi GOZLAN ,  Esther TZEHOVAL ,  Nir FRIEDMAN ,  Erez GREENSTEIN

IPC: C07K14/725 ,  C12N9/78 ,  A61K39/00 ,  A61P35/00

CPC classification number: C07K14/7051 ,  C12Y305/04005 ,  C12N9/78 ,  A61K39/4632 ,  A61K39/4611 ,  A61K39/464486 ,  A61P35/00 ,  A61K39/4637 ,  A61K2239/25

Abstract: MAGE-A1 specific T cell receptors (TCRs) are provided. Accordingly, there is provided a TCR comprising a TCR α chain as set forth in SEQ ID NO: 1 having at least one mutation at an amino acid position selected from the group consisting of S189, G125, W55 and Y56; and/or a TCR β chain as set forth in SEQ ID NO: 2 having at least one mutation at an amino acid position selected from the group consisting of S32, S109 and T63, the TCR binds a MAGE-A1 peptide as set forth in SEQ ID NO: 25. Also provided are polynucleotides encoding the TCR and T cells expressing same and methods of use thereof.