公开(公告)号：US20170348393A1

公开(公告)日：2017-12-07

申请号：US15524634

申请日：2015-11-05

Applicant: Yeda Research And Development Co., Ltd.

Inventor： Michal SCHWARTZ-EISENBACH ,  Ido AMIT ,  Merav COHEN ,  Orit MATCOVICH

IPC: A61K38/21

CPC classification number: A61K38/215 ,  A61K9/0085 ,  A61P25/28

Abstract: A method of upregulating an anti-inflammatory response in a central nervous system (CNS) of a subject in need thereof is disclosed. The method comprising locally administering to the CNS of the subject a therapeutically effective amount of IFN-beta, thereby upregulating the anti-inflammatory response in the CNS of the subject. Methods of treating an inflammation in a CNS or treating a disease, disorder, condition or injury of a CNS of a subject are also disclosed.

公开(公告)号：US20160280739A1

公开(公告)日：2016-09-29

申请号：US15180031

申请日：2016-06-12

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michal SCHWARTZ-EISENBACH ,  Matityahu FRIDKIN ,  Michal CARDON-YAAKOV

IPC: C07K7/06 ,  A61K9/00

CPC classification number: C07K7/06 ,  A61K9/0053 ,  A61K38/00 ,  C07K7/64

Abstract: The present application provides synthetic modified peptides of five to seven natural or non-natural amino acids as well as pharmaceutical compositions comprising them, for use in the treatment a disease or disorder presenting behavioral abnormalities associated with impairment of sensory gating function, depression or cognitive impairment, particularly schizophrenia and Alzheimer's disease.

Abstract translation: 本申请提供五至七个天然或非天然氨基酸的合成修饰肽以及包含它们的药物组合物，用于治疗与感觉门控功能障​​碍，抑郁症或认知障碍相关的行为异常的疾病或病症 ，特别是精神分裂症和阿尔茨海默病。