公开(公告)号：US11179437B2

公开(公告)日：2021-11-23

申请号：US16899647

申请日：2020-06-12

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michal Sharon ,  Maria Gabriella Fuzesi-Levi

IPC: A61K38/10 ,  C12N15/113

Abstract: A method of treating a condition associated with aberrant protein degradation is disclosed. The method comprises administering to a subject in need thereof a therapeutically effective amount of an agent, which reduces the amount of CSN Acidic Protein (CSNAP) which is incorporated into the COP9 signalosome complex (CSN) of the cell.

公开(公告)号：US20200297796A1

公开(公告)日：2020-09-24

申请号：US16899647

申请日：2020-06-12

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michal Sharon ,  Maria Gabriella Fuzesi-Levi

IPC: A61K38/10 ,  C12N15/113

Abstract: A method of treating a condition associated with aberrant protein degradation is disclosed. The method comprises administering to a subject in need thereof a therapeutically effective amount of an agent, which reduces the amount of CSN Acidic Protein (CSNAP) which is incorporated into the COP9 signalosome complex (CSN) of the cell.