公开(公告)号：US20230364062A1

公开(公告)日：2023-11-16

申请号：US18134064

申请日：2023-04-13

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Liran SHLUSH ,  Tom FLEISCHER ,  Benjamin GEIGER ,  Minhua SU

IPC: A61K31/426 ,  C12Q1/6827 ,  A61P35/02

CPC classification number: A61K31/426 ,  C12Q1/6827 ,  A61P35/02

Abstract: A method is disclosed for treating or preventing a myeloid malignancy in a subject harboring a mutation in SRSF2 comprising:



(a) analyzing in a sample of the subject for the presence of an SRSF2 mutation; and
(b) administering to the subject a therapeutically effective amount of a Rho Kinase inhibitor, or an inhibitor of a downstream effector thereof, upon identification of SRSF2 mutation.