公开(公告)号：US10849985B2

公开(公告)日：2020-12-01

申请号：US15573550

申请日：2016-05-19

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Valery Krizhanovsky ,  Yossi Ovadya

IPC: A61K47/68 ,  A61P35/00 ,  A61K45/06 ,  C07K16/18 ,  C12N15/113

Abstract: A method of targeting a pharmaceutical agent to a senescent cell is disclosed. The method comprises administering the pharmaceutical agent to the subject, wherein said pharmaceutical agent is attached to an affinity moiety, said affinity moiety being capable of binding specifically to a polypeptide selected from the group consisting of HSP90B1, DNAJB4, PI4K2A, DBN1, PRKCSH, SPTBN1, NPM1, ITGA3 and a polypeptide set forth in Table 1. The targeting may be for therapeutics or diagnostics.

公开(公告)号：US11865184B2

公开(公告)日：2024-01-09

申请号：US17075738

申请日：2020-10-21

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Valery Krizhanovsky ,  Yossi Ovadya

IPC: A61K47/68 ,  A61P35/00 ,  A61K45/06 ,  C07K16/18 ,  C12N15/113

CPC classification number: A61K47/6843 ,  A61K45/06 ,  A61K47/6807 ,  A61K47/6849 ,  A61P35/00 ,  C07K16/18 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/3513

Abstract: A method of targeting a pharmaceutical agent to a senescent cell is disclosed. The method comprises administering the pharmaceutical agent to the subject, wherein said pharmaceutical agent is attached to an affinity moiety, said affinity moiety being capable of binding specifically to a polypeptide selected from the group consisting of HSP90B1, DNAJB4, PI4K2A, DBN1, PRKCSH, SPTBN1, NPM1, ITGA3 and a polypeptide set forth in Table 1. The targeting may be for therapeutics or diagnostics.