公开(公告)号：US20220106405A1

公开(公告)日：2022-04-07

申请号：US17429672

申请日：2020-02-10

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Vishnu MOHAN

IPC: C07K16/40 ,  C07K16/30 ,  A61P35/00 ,  A61K31/282 ,  A61K31/7068

Abstract: An antibody comprising an antigen recognition region which binds a catalytic site of MMP-7, having complementarity determining region (CDR) amino acid sequences as set forth in: SEQ ID NOs: 3 (CDR1), 4 (CDR2) and 5 (CDR3), sequentially arranged from N to C on a light chain of the antibody; and SEQ ID NOs: 6 (CDR1), 7 (CDR2) and 8 (CDR3), sequentially arranged from N to C on a heavy chain of the antibody.