公开(公告)号：US20210292338A1

公开(公告)日：2021-09-23

申请号：US17337570

申请日：2021-06-03

申请人： Yeda Research and Development Co. Ltd. ,  Universitat de Barcelona ,  Institució Catalana de Recerca I Estudis Avançats

发明人： Rony SEGER ,  Karen FLORES ,  Xavier BARRIL ALONSO ,  Carlos GALDEANO CANTADOR

IPC分类号： C07D498/04 ,  A61K45/06 ,  A61P35/00

摘要： Described herein are compounds having Formula I or Formula II: wherein each dashed line independently represents a saturated or unsaturated bond; R1 and R′1 are aryl or heteroaryl as defined herein; and R2 and R′2 are as defined herein. Further described is a method of inhibiting nuclear translocation of ERK1/2 in a cell, by contacting the cell with a compound having Formula I or Formula II. The compounds may also be for use in treating a disease or disorder associated with nuclear translocation of ERK1/2.

公开(公告)号：US20240208998A1

公开(公告)日：2024-06-27

申请号：US18556456

申请日：2022-04-21

申请人： FUNDACIÓ PRIVADA INSTITUT D'INVESTIGACIÓ ONCOLÓGICA DE VALL HEBRON ,  UNIVERSITAT DE BARCELONA ,  INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS

发明人： Héctor GARCÍA PALMER ,  Isabel PUIG BORREIL ,  Josep TABERNERO CATURLA ,  Carlos GALDEANO CANTADOR ,  Diego MUÑOZ-TORRERO LÓPEZ-IBARRA ,  Xavier BARRIL ALONSO ,  Sergio RUIZ CARMONA

IPC分类号： C07D513/04 ,  A61K31/427 ,  A61K31/429 ,  A61P35/00 ,  C07D417/14 ,  C07D519/00

CPC分类号： C07D513/04 ,  A61K31/427 ,  A61K31/429 ,  A61P35/00 ,  C07D417/14 ,  C07D519/00

摘要： The present invention relates to 2-aminothiazol or 2-aminooxazol derivatives or pharmaceutically acceptable salt thereof for use in the treatment of hyperproliferative disorders, to method of treatment and/or prevention of hyperproliferative disorders using said compounds and to a subgroup of said derivatives which are new.