公开(公告)号：US06489449B2

公开(公告)日：2002-12-03

申请号：US09834628

申请日：2001-04-16

申请人： Yeon Gyu Yu ,  Key-Sun Kim ,  Bong-Suk Jin

发明人： Yeon Gyu Yu ,  Key-Sun Kim ,  Bong-Suk Jin

IPC分类号： C07K1600

CPC分类号： A61K38/10

摘要： The present invention relates to peptides that can inhibit the infection of HIV, and more particularly, to peptides consisting of less than 30 amino acids which can introduce a helix capping motif into a peptide derived from C-terminal helical region (its 628-646th amino acid region) of gp41, an envelope glycoprotein of HIV, as well as consisting of the symmetrical bivalent peptide through the introduction of a branched amino acid, Fmoc-Lys(Fmoc)-OH at C-terminus of its peptide, and induce a more stable helical structure thus inhibiting the infection of HIV.

摘要翻译： 本发明涉及可以抑制HIV感染的肽，更具体地说，涉及由少于30个氨基酸组成的肽，其可以将衍生自C末端螺旋区的肽（其第628-646位氨基 酸性区域）gp41，HIV的包膜糖蛋白，以及通过在其肽的C末端引入支链氨基酸Fmoc-Lys（Fmoc）-OH的对称二价肽组成，并诱导更多的 稳定的螺旋结构从而抑制HIV的感染。