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公开(公告)号：US07934832B2
公开(公告)日：2011-05-03
申请号：US12176550
申请日：2008-07-21
IPC分类号： A61B3/10
CPC分类号： A61B3/1005 , A61B3/102 , A61B3/1225
摘要： Disclosed are method and apparatus for characterizing the retinal nerve fiber layer (RNFL). An advantageous diagnostic parameter for characterizing the RNFL is a function of the product of the local RNFL thickness at a measurement locus×the distance of the measurement locus from a base point. The value of the diagnostic parameter in a patient's retina is compared to a corresponding reference range acquired from a population of healthy retinas.
摘要翻译： 公开了用于表征视网膜神经纤维层（RNFL）的方法和装置。 用于表征RNFL的有利的诊断参数是测量轨迹上的局部RNFL厚度×测量轨迹距离基点的距离的乘积的函数。 将患者视网膜中的诊断参数的值与从健康视网膜群体获得的对应参考范围进行比较。
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公开(公告)号：US20100290005A1
公开(公告)日：2010-11-18
申请号：US12465750
申请日：2009-05-14
CPC分类号： G06T11/206 , A61B3/0025 , A61B3/102
摘要： Certain diseases of the retina are diagnosed by circular profile analysis of retinal parameters, such as thickness. Retinal thickness around a user-defined circle on the retina is measured by various ophthalmological techniques and ±mapped to a circular profile map. The circular profile map does not use segmentation of measurement data into arbitrary arcs, and thickness is mapped to a quasi-continuous range of display bands. The circular profile map is superimposed on a fundus image, or other two-dimensional image of the retina, allowing association of the circular profile map with the presence of blood vessels and other anatomical features. The simultaneous display of a series of circular profile maps generated from sets of measurement data taken at different times permits the ready visualization of the progression of retinal abnormalities.
摘要翻译： 通过视网膜参数（如厚度）的圆形剖面分析诊断视网膜的某些疾病。 通过各种眼科技术测量视网膜上用户定义的圆周围的视网膜厚度，并将其映射到圆形轮廓图。 圆形剖面图不将测量数据分割成任意弧，厚度映射到显示带的准连续范围。 圆形轮廓图叠加在眼底图像或视网膜的其他二维图像上，允许圆形轮廓图与血管和其他解剖特征的存在相关联。 同时显示由不同时间采集的测量数据组生成的一系列圆形轮廓图允许准确地观察视网膜异常的进展。
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3.发明授权Method and apparatus for spatially mapping three-dimensional optical coherence tomography data with two-dimensional images 有权用三维光学相干断层扫描数据与二维图像进行空间映射的方法和装置公开(公告)号：US08134554B1
公开(公告)日：2012-03-13
申请号：US11800186
申请日：2007-05-04
IPC分类号： G06T17/00
CPC分类号： G06T11/008 , G06T7/33 , G06T2207/10101 , G06T2207/20101 , G06T2207/30041
摘要： Voxel data from a three-dimensional optical coherence tomography (3-D OCT) scan of a retina and pixel data from a two-dimensional (2-D) fundus image are spatially mapped. A 2-D composite image generated from the 3-D OCT data is spatially mapped to a fundus image using spatial indicia common to both images. The 3-D OCT data is then spatially mapped to the fundus image. An image processing system generates cross-correlated graphical representations of 3-D OCT data, subsets of 3-D OCT data, and a fundus image.
摘要翻译： 来自二维（2-D）眼底图像的视网膜的三维光学相干断层扫描（3-D OCT）扫描和像素数据的体素数据被空间映射。 从三维OCT数据生成的2-D合成图像使用两个图像共同的空间标记在空间上映射到眼底图像。 然后将3-OCT OCT数据空间映射到眼底图像。 图像处理系统产生三维OCT数据，三维OCT数据子集和眼底图像的相互关联图形表示。
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公开(公告)号：US20100290004A1
公开(公告)日：2010-11-18
申请号：US12465724
申请日：2009-05-14
IPC分类号： A61B3/10
CPC分类号： A61B3/1225
摘要： Certain diseases of the retina are diagnosed by circular profile analysis of retinal parameters, such as thickness. Retinal thickness around a user-defined circle on the retina is measured by three-dimensional optical coherence tomography or other ophthalmological techniques. Abnormally thin regions are identified by comparing a measured function of thickness vs. polar angle to a reference function of thickness vs. polar angle. A degree of abnormality is characterized by the ratio of the integral of the measured thickness function to the integral of the reference thickness function over the abnormally thin region, as specified by a range of polar angles.
摘要翻译： 通过视网膜参数（如厚度）的圆形剖面分析诊断视网膜的某些疾病。 通过三维光学相干断层扫描或其他眼科技术测量视网膜上用户定义圆周围的视网膜厚度。 通过将厚度与极角的测量函数与厚度与极角的参考函数进行比较来识别异常薄的区域。 异常程度的特征在于，如极角范围所规定的，测量厚度函数的积分与参考厚度函数的积分在非常薄的区域上的比率。
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公开(公告)号：US08567951B2
公开(公告)日：2013-10-29
申请号：US13224568
申请日：2011-09-02
IPC分类号： A61B3/00
CPC分类号： A61B3/1225
摘要： Certain diseases of the retina are diagnosed by circular profile analysis of retinal parameters, such as thickness. Retinal thickness around a user-defined circle on the retina is measured by three-dimensional optical coherence tomography or other ophthalmological techniques. Abnormally thin regions are identified by comparing a measured function of thickness vs. polar angle to a reference function of thickness vs. polar angle. A degree of abnormality is characterized by the ratio of the integral of the measured thickness function to the integral of the reference thickness function over the abnormally thin region, as specified by a range of polar angles.
摘要翻译： 通过视网膜参数（如厚度）的圆形剖面分析诊断视网膜的某些疾病。 通过三维光学相干断层扫描或其他眼科技术测量视网膜上用户定义圆周围的视网膜厚度。 通过将厚度与极角的测量函数与厚度与极角的参考函数进行比较来识别异常薄的区域。 异常程度的特征在于，如极角范围所规定的，测量厚度函数的积分与参考厚度函数的积分在非常薄的区域上的比率。
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6.发明授权Retinal thickness measurement by combined fundus image and three-dimensional optical coherence tomography 有权通过组合眼底图像和三维光学相干断层扫描的视网膜厚度测量公开(公告)号：US08081808B2
公开(公告)日：2011-12-20
申请号：US12262620
申请日：2008-10-31
CPC分类号： A61B3/1225 , A61B3/0033 , A61B3/0058 , A61B3/1005 , A61B3/102 , A61B3/145
摘要： Disclosed are method and apparatus for mapping retinal thickness values to a movable measurement grid. A three-dimensional volume dataset acquired from three-dimensional optical coherence tomography is registered to a fundus image by rendering a two-dimensional composite image from the three-dimensional volume dataset and superimposing characteristic features in the two-dimensional composite image upon corresponding characteristic features in the fundus image. A measurement grid is displayed on the two-dimensional composite image. The measurement grid is moved to a region of interest, and retinal thickness values in the region of interest are mapped to sectors within the measurement grid.
摘要翻译： 公开了用于将视网膜厚度值映射到可移动测量网格的方法和装置。 从三维光学相干断层扫描获取的三维体数据集通过从三维体数据集中渲染二维合成图像并将二维合成图像中的特征叠加在相应的特征特征上而登记到眼底图像 在眼底的形象。 测量网格显示在二维合成图像上。 将测量网格移动到感兴趣区域，并将感兴趣区域中的视网膜厚度值映射到测量网格内的扇区。
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7.发明授权Mapping of retinal parameters from combined fundus image and three-dimensional optical coherence tomography 有权来自组合眼底图像和三维光学相干断层扫描的视网膜参数的映射公开(公告)号：US08401246B2
公开(公告)日：2013-03-19
申请号：US12262799
申请日：2008-10-31
IPC分类号： G06K9/00
CPC分类号： A61B3/145 , A61B3/0058 , A61B3/1005 , A61B3/1225 , A61B5/7425
摘要： A second retinal characterization data set is mapped to a first retinal characterization dataset. The first retinal characterization dataset is displayed as a first graphical map. The second retinal characterization dataset is displayed as a second graphical map which is mapped to the first graphical map. The second graphical map may be warped and morphed onto the first graphical map. Retinal characterization datasets may be derived either from a fundus image or from a retinal parameter dataset calculated from a three-dimensional optical coherence tomography scan of a retina. Retinal parameter datasets may characterize parameters such as retinal thickness. In an embodiment, a fundus image is warped and morphed onto a retinal surface topographical map.
摘要翻译： 将第二视网膜表征数据集映射到第一视网膜表征数据集。 第一个视网膜表征数据集显示为第一个图形图。 第二个视网膜表征数据集显示为映射到第一个图形图的第二个图形图。 第二个图形图可能会变形并变形到第一个图形图上。 视网膜特征数据集可以从眼底图像或从视网膜的三维光学相干断层扫描计算的视网膜参数数据集中得出。 视网膜参数数据集可以表征视网膜厚度等参数。 在一个实施例中，眼底图像变形并变形到视网膜表面形貌图上。
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公开(公告)号：US20120002170A1
公开(公告)日：2012-01-05
申请号：US13224568
申请日：2011-09-02
IPC分类号： A61B3/10
CPC分类号： A61B3/1225
摘要： Certain diseases of the retina are diagnosed by circular profile analysis of retinal parameters, such as thickness. Retinal thickness around a user-defined circle on the retina is measured by three-dimensional optical coherence tomography or other ophthalmological techniques. Abnormally thin regions are identified by comparing a measured function of thickness vs. polar angle to a reference function of thickness vs. polar angle. A degree of abnormality is characterized by the ratio of the integral of the measured thickness function to the integral of the reference thickness function over the abnormally thin region, as specified by a range of polar angles.
摘要翻译： 通过视网膜参数（如厚度）的圆形剖面分析诊断视网膜的某些疾病。 通过三维光学相干断层扫描或其他眼科技术测量视网膜上用户定义圆周围的视网膜厚度。 通过将厚度与极角的测量函数与厚度与极角的参考函数进行比较来识别异常薄的区域。 异常程度的特征在于，如极角范围所规定的，测量厚度函数的积分与参考厚度函数的积分在非常薄的区域上的比率。
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9.发明申请Retinal Thickness Measurement by Combined Fundus Image and Three-Dimensional Optical Coherence Tomography 有权组合眼底图像和三维光学相干断层扫描的视网膜厚度测量公开(公告)号：US20090123044A1
公开(公告)日：2009-05-14
申请号：US12262620
申请日：2008-10-31
IPC分类号： G06K9/00
CPC分类号： A61B3/1225 , A61B3/0033 , A61B3/0058 , A61B3/1005 , A61B3/102 , A61B3/145
摘要： Disclosed are method and apparatus for mapping retinal thickness values to a movable measurement grid. A three-dimensional volume dataset acquired from three-dimensional optical coherence tomography is registered to a fundus image by rendering a two-dimensional composite image from the three-dimensional volume dataset and superimposing characteristic features in the two-dimensional composite image upon corresponding characteristic features in the fundus image. A measurement grid is displayed on the two-dimensional composite image. The measurement grid is moved to a region of interest, and retinal thickness values in the region of interest are mapped to sectors within the measurement grid.
摘要翻译： 公开了用于将视网膜厚度值映射到可移动测量网格的方法和装置。 从三维光学相干断层扫描获取的三维体数据集通过从三维体数据集中渲染二维合成图像并将二维合成图像中的特征叠加在相应的特征特征上而登记到眼底图像 在眼底的形象。 测量网格显示在二维合成图像上。 将测量网格移动到感兴趣区域，并将感兴趣区域中的视网膜厚度值映射到测量网格内的扇区。
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公开(公告)号：US08256897B2
公开(公告)日：2012-09-04
申请号：US12465750
申请日：2009-05-14
CPC分类号： G06T11/206 , A61B3/0025 , A61B3/102
摘要： Certain diseases of the retina are diagnosed by circular profile analysis of retinal parameters, such as thickness. Retinal thickness around a user-defined circle on the retina is measured by various ophthalmological techniques and—+mapped to a circular profile map. The circular profile map does not use segmentation of measurement data into arbitrary arcs, and thickness is mapped to a quasi-continuous range of display bands. The circular profile map is superimposed on a fundus image, or other two-dimensional image of the retina, allowing association of the circular profile map with the presence of blood vessels and other anatomical features. The simultaneous display of a series of circular profile maps generated from sets of measurement data taken at different times permits the ready visualization of the progression of retinal abnormalities.
摘要翻译： 通过视网膜参数（如厚度）的圆形剖面分析诊断视网膜的某些疾病。 通过各种眼科技术测量视网膜上用户定义的圆周围的视网膜厚度，并将其映射到圆形轮廓图。 圆形剖面图不将测量数据分割成任意弧，厚度映射到显示带的准连续范围。 圆形轮廓图叠加在眼底图像或视网膜的其他二维图像上，允许圆形轮廓图与血管和其他解剖特征的存在相关联。 同时显示由不同时间采集的测量数据组生成的一系列圆形轮廓图允许准确地观察视网膜异常的进展。
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