公开(公告)号：US08902420B2

公开(公告)日：2014-12-02

申请号：US13337340

申请日：2011-12-27

申请人： Yon-Hua Tzeng ,  Chih-Yi Liu ,  Chen-Han Huang ,  Hsing-Ying Lin ,  Hsiang-Chen Chui ,  Kyaw-Oo Lau ,  Shih-Tse Chen ,  Cheng-Wen Huang

发明人： Yon-Hua Tzeng ,  Chih-Yi Liu ,  Chen-Han Huang ,  Hsing-Ying Lin ,  Hsiang-Chen Chui ,  Kyaw-Oo Lau ,  Shih-Tse Chen ,  Cheng-Wen Huang

IPC分类号： G01J3/44 ,  G01N21/65

CPC分类号： G01N21/658

摘要： The present invention relates to a sensor chip for biomedical and micro-nano structured substances and a method for manufacturing the same. The sensor chip includes plural metal nanoparticles and a porous anodized aluminum oxide film. The plural metal nanoparticles are completely contained in holes of the porous anodized aluminum oxide film and located at the bottom of the holes, and an aluminum oxide layer covering the second end of the holes has a thickness of 1 nm to 300 nm. When analytes such as biomedical molecules are provided in contact with the sensor chip, a Raman signal can be detected based on the Raman spectroscopy. The structure of the sensor chip of the present invention is uncomplicated and the manufacturing steps thereof are simple, and therefore the sensor chip of the present invention is of great commercial value. Also, a method of manufacturing the above sensor chip is disclosed.

摘要翻译： 本发明涉及用于生物医学和微纳米结构物质的传感器芯片及其制造方法。 传感器芯片包括多个金属纳米颗粒和多孔阳极化氧化铝膜。 多孔金属纳米粒子完全包含在多孔阳极化氧化铝膜的孔中，位于孔的底部，覆盖孔的第二端的氧化铝层的厚度为1nm〜300nm。 当分析物如生物医学分子与传感器芯片接触时，可以基于拉曼光谱法检测拉曼信号。 本发明的传感器芯片的结构简单，其制造步骤简单，因此本发明的传感器芯片具有很大的商业价值。 另外，公开了制造上述传感器芯片的方法。

公开(公告)号：US20120194813A1

公开(公告)日：2012-08-02

申请号：US13337340

申请日：2011-12-27

申请人： Yon-Hua TZENG ,  Chih-Yi Liu ,  Chen-Han Huang ,  Hsing-Ying Lin ,  Hsiang-Chen Chui ,  Kyaw-Oo Lau ,  Shih-Tse Chen ,  Cheng-Wen Huang

发明人： Yon-Hua TZENG ,  Chih-Yi Liu ,  Chen-Han Huang ,  Hsing-Ying Lin ,  Hsiang-Chen Chui ,  Kyaw-Oo Lau ,  Shih-Tse Chen ,  Cheng-Wen Huang

IPC分类号： G01J3/44 ,  C25D1/00 ,  B82Y40/00

CPC分类号： G01N21/658

摘要： The present invention relates to a sensor chip for biomedical and micro-nano structured substances and a method for manufacturing the same. The sensor chip includes plural metal nanoparticles and a porous anodized aluminum oxide film. The plural metal nanoparticles are completely contained in holes of the porous anodized aluminum oxide film and located at the bottom of the holes, and an aluminum oxide layer covering the second end of the holes has a thickness of 1 nm to 300 nm. When analytes such as biomedical molecules are provided in contact with the sensor chip, a Raman signal can be detected based on the Raman spectroscopy. The structure of the sensor chip of the present invention is uncomplicated and the manufacturing steps thereof are simple, and therefore the sensor chip of the present invention is of great commercial value. Also, a method of manufacturing the above sensor chip is disclosed.

摘要翻译： 本发明涉及用于生物医学和微纳米结构物质的传感器芯片及其制造方法。 传感器芯片包括多个金属纳米颗粒和多孔阳极化氧化铝膜。 多孔金属纳米粒子完全包含在多孔阳极化氧化铝膜的孔中，位于孔的底部，覆盖孔的第二端的氧化铝层的厚度为1nm〜300nm。 当分析物如生物医学分子与传感器芯片接触时，可以基于拉曼光谱法检测拉曼信号。 本发明的传感器芯片的结构简单，其制造步骤简单，因此本发明的传感器芯片具有很大的商业价值。 另外，公开了制造上述传感器芯片的方法。