公开(公告)号：US20050059832A1

公开(公告)日：2005-03-17

申请号：US10823707

申请日：2004-04-14

申请人： Yong Cho ,  Moon Chang ,  Hun Koh ,  Ae Pae ,  Hyun Kang

发明人： Yong Cho ,  Moon Chang ,  Hun Koh ,  Ae Pae ,  Hyun Kang

IPC分类号： C07B61/00 ,  C07D493/08 ,  C07D493/04

CPC分类号： C07D493/08

摘要： The present invention relates to a synthesis of a 7-membered carbocyclic compound having diexomethylene groups, more particularly to a synthesis of a 7-membered carbocyclic compound having diexomethylene groups, a novel compound having the structure represented by the following Chemical Formula 1, from trimethylsilanylmethyl-allenol derivative by the intramolecular Prins cyclization using Lewis acid. The 7-membered carbocyclic compound is a useful intermediate for synthesis of other multicyclic compounds. In Chemical Formula 1, R1 is a C1 to C6 alkyl group, and R2 and R3 is respectively a hydrogen atom, or R1, R2 and R3 may be connected with neighboring substituents to form a 5 to 10-membered aliphatic or aromatic ring.

摘要翻译： 本发明涉及具有阴离子亚甲基的7-元碳环化合物的合成，更具体地说，涉及具有下式化学式1所示结构的新化合物，具有三亚甲基硅烷基甲基的三元碳环化合物 通过使用路易斯酸的分子内Prins环化形成的α-烯醇衍生物。 7元碳环化合物是合成其他多环化合物的有用中间体。 在化学式1中，R 1是C 1 -C 6烷基，R 2和R 3分别是氢原子，或者R 1，R 2和R 3可以是 与相邻取代基连接形成5至10元脂族或芳环。

公开(公告)号：US20050059732A1

公开(公告)日：2005-03-17

申请号：US10823708

申请日：2004-04-14

申请人： Yong Cho ,  Moon Chang ,  Hun Koh ,  Ae Pae ,  Hyun Kang

发明人： Yong Cho ,  Moon Chang ,  Hun Koh ,  Ae Pae ,  Hyun Kang

IPC分类号： A61K31/343 ,  C07B61/00 ,  C07D493/08 ,  C07D493/02

CPC分类号： C07D493/08 ,  A61K31/343

摘要： The present invention relates to a synthesis of an 8-membered carbocyclic compound having diexomethylene groups, more particularly to a synthesis of an 8-membered carbocyclic compound having diexomethylene groups, a novel compound having the structure represented by the following Chemical Formula 1, from trimethylsilanylmethyl-allenol derivative by the intramolecular Prins cyclization using Lewis acid. The 8-membered carbocyclic compound is a useful intermediate for synthesis of other multicarbocyclic compounds. In Chemical Formula 1, R1 is a phenyl group, and R2 and R3 is a hydrogen atom, or R1, R2 and R3 may be connected with neighboring substituents to form a 5 to 10-membered aliphatic or aromatic ring.

摘要翻译： 本发明涉及具有阴离子亚甲基的8-元碳环化合物的合成，更具体地说，涉及一种具有下式化学式1所示结构的新化合物，具有三亚甲基硅烷基甲基 通过使用路易斯酸的分子内Prins环化形成的α-烯醇衍生物。 8元碳环化合物是合成其它多碳环化合物的有用中间体。 在化学式1中，R 1是苯基，R 2和R 3是氢原子，或者R 1，R 2和R 3可以与相邻的取代基连接 以形成5至10元脂族或芳族环。