公开(公告)号：US10109644B2

公开(公告)日：2018-10-23

申请号：US15385152

申请日：2016-12-20

申请人： Yoo Cheol Shin ,  Tae Hun Kim

发明人： Yoo Cheol Shin ,  Tae Hun Kim

IPC分类号： H01L27/11582 ,  H01L23/535 ,  H01L29/36 ,  H01L29/423 ,  H01L27/11565 ,  H01L27/1157 ,  H01L27/11573 ,  H01L27/11575

摘要： In one embodiment, the semiconductor device includes a substrate having an impurity region, and the substrate and the impurity region have a different impurity characteristic. The semiconductor device further includes a stack of alternating first interlayer insulating layers and gate electrode layers on the substrate; at least one second interlayer insulating layer formed on the stack; a plurality of bit lines formed on the second interlayer insulating layer; and a first plurality of channel structures formed through the stack on the substrate. The first plurality of channel structures are electrically connected to respective ones of the plurality of bit lines. A second plurality of channel structures are formed through the stack on the impurity region, and the second plurality of channel structures are electrically insulated from the plurality of bit lines.

公开(公告)号：US06180761B2

公开(公告)日：2001-01-30

申请号：US09269220

申请日：1999-03-23

申请人： Sang Kee Han ,  Yoo Cheol Shin

发明人： Sang Kee Han ,  Yoo Cheol Shin

IPC分类号： C07K100

CPC分类号： C07K14/4732 ,  A01K67/027 ,  A23J1/202 ,  A23L33/19

摘要： A new casein is disclosed isolated from the milk of Korean cattle with a &bgr;-casein A1H genotype. Amino acid sequence analysis of the casein revealed a length of 209 amino acids, where, in comparison to the more conventional &bgr;-casein variant A2, at amino acid position 25, Arg is replaced by Cys, at position 88, Leu is replaced by Ile, at position 117, Gln is replaced by Glu, at position 175, Glu is replaced by Gln, and at position 195, Gln is replaced by Glu. The new casein variant disclosed can be mass produced by the selective breeding of individual bovines to produce large quantities of milk containing the new casein variant. In one example of such breeding, a female calf was born that subsequently produced the inventive casein at a yield of 4.5 kg per day. The new casein gene can be detected DNA hybridization analysis in bovines secreting the new casein. The new casein increases the absorption of casein from the small intestine about 5% in the upper region of the small intestine and about 20% in the lower region of the small intestine. Thus, this new casein can be formulated in to foodstuffs, such as infant formula, dairy products, and to treat diseases, such as osteoporosis and anemia. Further, the new casein can also be formulated into skin and hair products.

摘要翻译： 公开了一种新的酪蛋白，其分离自具有β-酪蛋白A1H基因型的韩国牛的牛奶。 酪蛋白的氨基酸序列分析显示长度为209个氨基酸，其中与更常规的β-酪蛋白变体A2相比，在氨基酸位置25处，Arg被Cys替代，在第88位，Leu被Ile取代 ，在位置117，Gln被Glu替代，在位置175，Glu被Gln替代，而在195位，Gln被Glu取代。 所公开的新的酪蛋白变体可以通过选择性育种各种牛来大量生产，以产生含有新酪蛋白变体的大量牛奶。 在这种育种的一个实例中，出生了雌性小牛，随后以4.5kg /天的产量生产本发明的酪蛋白。 新的酪蛋白基因可以在分泌新酪蛋白的牛中检测DNA杂交分析。 新型酪蛋白在小肠上部区域增加小肠中酪蛋白的吸收约5％，小肠下部的吸收增加约20％。 因此，这种新型酪蛋白可以配制成食品，如婴儿配方食品，乳制品，以及治疗骨质疏松症和贫血等疾病。 此外，新的酪蛋白也可以配制成皮肤和头发产品。

公开(公告)号：US5834427A

公开(公告)日：1998-11-10

申请号：US621564

申请日：1996-03-25

申请人： Sang Kee Han ,  Yoo Cheol Shin

发明人： Sang Kee Han ,  Yoo Cheol Shin

IPC分类号： A23J1/20 ,  A23J3/10 ,  A23K1/16 ,  A23L1/303 ,  A23L1/304 ,  A23L1/305 ,  A61K38/00 ,  A61K38/17 ,  A61P1/02 ,  C07K1/18 ,  C07K1/26 ,  C07K1/30 ,  C07K14/47

CPC分类号： A23J1/202 ,  A23J3/10 ,  A23K20/147 ,  A23L33/19 ,  C07K14/4732 ,  A61K38/00 ,  Y10S514/902

摘要： The present invention relates to a purified casein phosphopeptide(CPP) having a novel amino acid sequence and a purified casein including same wherein the 25th Arg from N-terminal in a conventional CPP is replaced by Cys, rendering the CPPs to forming a dimer by disulfide bond. In the corresponding DNA sequence, cytosine is replaced by thymine to cause the amino acid replacement from Arginine(Arg) to Cysteine(Cys). The CPP or the casein containing same has an improved ability of solubilizing minerals and absorbing thereof in animals. The CPP or the beta-casein H containing same can be added to foodstuffs, beverages, medication, cosmetics, feed in an effective amount of enhancing a mineral absorption in animals. An oral composition comprising the beta-casein H or the inventive CPP and a pharmaceutically acceptable carrier can reduce or relieve a dentinal hypersensitivity.

摘要翻译： 本发明涉及具有新氨基酸序列的纯化酪蛋白磷酸肽（CPP）和包含其的纯化酪蛋白，其中常规CPP中N末端的第25位Arg被Cys取代，使得CPP通过二硫键形成二聚体 键。 在相应的DNA序列中，胞嘧啶被胸腺嘧啶替代，导致从精氨酸（Arg）到半胱氨酸（Cys）的氨基酸置换。 含有CPP或含酪蛋白的动物具有改善矿物质溶解能力和吸收能力。 含有相同的CPP或β-酪蛋白H可以有效增加食物，饮料，药物，化妆品，饲料中增加动物的矿物质吸收。 包含β-酪蛋白H或本发明的CPP和药学上可接受的载体的口服组合物可以减少或减轻牙质过敏。