公开(公告)号：US20110092506A1

公开(公告)日：2011-04-21

申请号：US12973403

申请日：2010-12-20

申请人： Yoshinori NAKAMURA ,  Norimitsu Hayashi ,  Takanori Higasahijima ,  Hitoshi Kubota ,  Kozo Oka

发明人： Yoshinori NAKAMURA ,  Norimitsu Hayashi ,  Takanori Higasahijima ,  Hitoshi Kubota ,  Kozo Oka

IPC分类号： A61K31/5377 ,  A61K31/506 ,  A61K31/505 ,  A61K31/498 ,  A61K31/41 ,  A61K31/44 ,  A61P9/10 ,  A61P9/00 ,  A61P3/10 ,  A61P3/00 ,  A61P9/12 ,  A61P3/04 ,  A61P7/02 ,  A61P25/00 ,  A61P9/06 ,  A61P11/00 ,  A61P13/12 ,  A61P1/16 ,  A61P29/00 ,  A61P37/02 ,  A61P15/00 ,  A61P35/00 ,  A61P25/28

CPC分类号： C07D239/47 ,  C07D239/42 ,  C07D239/48 ,  C07D239/52 ,  C07D239/56 ,  C07D257/06 ,  C07D401/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12

摘要： The present invention relates to a compound of the general formula (1): wherein, Y is a methylene group, and the like; A is an optionally substituted heterocyclic group, and the like; B is an optionally substituted phenyl group, and the like; R1 is an optionally substituted alkyl group, and the like; and R2 is an optionally substituted amino group, and the like; or a pharmaceutically acceptable derivative thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP), thereby being useful for prophylaxis and/or treatment of arteriosclerotic diseases, hyperlipemia or dyslipidemia, and the like.

摘要翻译： 本发明涉及通式（1）的化合物：其中Y为亚甲基等; A是任选取代的杂环基等; B是任选取代的苯基等; R1是任选取代的烷基等; 并且R 2是任选取代的氨基等; 或其药学上可接受的衍生物，其具有对胆固醇酯转移蛋白（CETP）的抑制活性，从而可用于预防和/或治疗动脉硬化性疾病，高脂血症或血脂异常等。