公开(公告)号：US08822422B2

公开(公告)日：2014-09-02

申请号：US13046082

申请日：2011-03-11

申请人： Yoshinori Naoe ,  Takeshi Inoue ,  Yasuhiko Kano

发明人： Yoshinori Naoe ,  Takeshi Inoue ,  Yasuhiko Kano

IPC分类号： A61K38/12 ,  A61P35/00 ,  C07K7/50 ,  A61K31/122 ,  A61K45/06 ,  A61K31/337

CPC分类号： A61K31/337 ,  A61K31/122 ,  A61K38/12 ,  A61K45/06 ,  A61K2300/00

摘要： An antitumor agent containing, in combination, at least one kind of antitumor agent selected from the group consisting of an antitumor agent that forms a cross-link with DNA and shows an antitumor effect, an antimetabolite antitumor agent and a taxane antitumor agent, and a histone deacetylase inhibitor. According to the present invention, an antitumor agent causing reduced side effects and having a superior antitumor activity can be provided.

摘要翻译： 一种抗肿瘤剂，其组合含有选自与DNA形成交联并显示抗肿瘤作用的抗肿瘤剂中的至少一种抗肿瘤剂，抗代谢物抗肿瘤剂和紫杉烷抗肿瘤剂，以及 组蛋白脱乙酰酶抑制剂。 根据本发明，可以提供引起副作用降低且抗肿瘤活性优异的抗肿瘤剂。

公开(公告)号：US07951780B2

公开(公告)日：2011-05-31

申请号：US11064292

申请日：2005-02-24

申请人： Yoshinori Naoe ,  Takeshi Inoue ,  Yasuhiko Kano

发明人： Yoshinori Naoe ,  Takeshi Inoue ,  Yasuhiko Kano

IPC分类号： A61K38/12 ,  A61P35/00

CPC分类号： A61K31/337 ,  A61K31/122 ,  A61K38/12 ,  A61K45/06 ,  A61K2300/00

摘要： An antitumor agent containing, in combination, at least one kind of antitumor agent selected from the group consisting of an antitumor agent that forms a cross-link with DNA and shows an antitumor effect, an antimetabolite antitumor agent and a taxane antitumor agent, and a histone deacetylase inhibitor. According to the present invention, an antitumor agent causing reduced side effects and having a superior antitumor activity can be provided.

摘要翻译： 一种抗肿瘤剂，其组合含有选自与DNA形成交联并显示抗肿瘤作用的抗肿瘤剂中的至少一种抗肿瘤剂，抗代谢物抗肿瘤剂和紫杉烷抗肿瘤剂，以及 组蛋白脱乙酰酶抑制剂。 根据本发明，可以提供引起副作用降低且抗肿瘤活性优异的抗肿瘤剂。

公开(公告)号：US20110160295A1

公开(公告)日：2011-06-30

申请号：US13046082

申请日：2011-03-11

申请人： Yoshinori Naoe ,  Takeshi Inoue ,  Yasuhiko Kano

发明人： Yoshinori Naoe ,  Takeshi Inoue ,  Yasuhiko Kano

IPC分类号： A61K31/337 ,  A61P35/00

CPC分类号： A61K31/337 ,  A61K31/122 ,  A61K38/12 ,  A61K45/06 ,  A61K2300/00

摘要： An antitumor agent containing, in combination, at least one kind of antitumor agent selected from the group consisting of an antitumor agent that forms a cross-link with DNA and shows an antitumor effect, an antimetabolite antitumor agent and a taxane antitumor agent, and a histone deacetylase inhibitor. According to the present invention, an antitumor agent causing reduced side effects and having a superior antitumor activity can be provided.

摘要翻译： 一种抗肿瘤剂，其组合含有选自与DNA形成交联并显示抗肿瘤作用的抗肿瘤剂中的至少一种抗肿瘤剂，抗代谢物抗肿瘤剂和紫杉烷抗肿瘤剂，以及 组蛋白脱乙酰酶抑制剂。 根据本发明，可以提供引起副作用降低且抗肿瘤活性优异的抗肿瘤剂。

公开(公告)号：US20050187149A1

公开(公告)日：2005-08-25

申请号：US11064292

申请日：2005-02-24

申请人： Yoshinori Naoe ,  Takeshi Inoue ,  Yasuhiko Kano

发明人： Yoshinori Naoe ,  Takeshi Inoue ,  Yasuhiko Kano

IPC分类号： A61K31/122 ,  A61K31/337 ,  A61K38/12

CPC分类号： A61K31/337 ,  A61K31/122 ,  A61K38/12 ,  A61K45/06 ,  A61K2300/00

摘要： An antitumor agent containing, in combination, at least one kind of antitumor agent selected from the group consisting of an antitumor agent that forms a cross-link with DNA and shows an antitumor effect, an antimetabolite antitumor agent and a taxane antitumor agent, and a histone deacetylase inhibitor. According to the present invention, an antitumor agent causing reduced side effects and having a superior antitumor activity can be provided.

公开(公告)号：US20050187148A1

公开(公告)日：2005-08-25

申请号：US10834080

申请日：2004-04-29

申请人： Yoshinori Naoe ,  Takeshi Inoue ,  Yasuhiko Kano

发明人： Yoshinori Naoe ,  Takeshi Inoue ,  Yasuhiko Kano

IPC分类号： A61K31/19 ,  A61K31/337 ,  A61K38/12 ,  A61K45/06

CPC分类号： A61K45/06 ,  A61K31/19 ,  A61K31/337 ,  A61K38/12 ,  A61K2300/00

摘要： An antitumor agent containing, in combination, at least one kind of antitumor agent selected from the group consisting of an antitumor agent that forms a cross-link with DNA and shows an antitumor effect, an antimetabolite antitumor agent and a taxane antitumor agent, and a histone deacetylase inhibitor. According to the present invention, an antitumor agent causing reduced side effects and having a superior antitumor activity can be provided.

摘要翻译： 一种抗肿瘤剂，其组合含有选自与DNA形成交联并显示抗肿瘤作用的抗肿瘤剂中的至少一种抗肿瘤剂，抗代谢物抗肿瘤剂和紫杉烷抗肿瘤剂，以及 组蛋白脱乙酰酶抑制剂。 根据本发明，可以提供引起副作用降低且抗肿瘤活性优异的抗肿瘤剂。