专利检索 ap:("Youhong Hu" OR "Jianping Zuo" OR "Dong Lu" OR "Li Yang" OR "Limin Zeng" OR "Feifei Liu" OR "Yunzhe Zhang" OR "Wuhong Chen" OR "Xiankun Tong") AND inv:"Yunzhe Zhang" 第 1 页

1.

发明申请
PHTHALAZINONE COMPOUND, METHOD FOR PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF 审中-公开

公开(公告)号：US20200181109A1

公开(公告)日：2020-06-11

申请号：US16786710

申请日：2020-02-10

申请人： Youhong Hu , Jianping Zuo , Dong Lu , Li Yang , Limin Zeng , Feifei Liu , Yunzhe Zhang , Wuhong Chen , Xiankun Tong

发明人： Youhong Hu , Jianping Zuo , Dong Lu , Li Yang , Limin Zeng , Feifei Liu , Yunzhe Zhang , Wuhong Chen , Xiankun Tong

IPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D405/14 , A61P31/20

摘要： Provided are a phthalazinone compound, method for preparation thereof, pharmaceutical composition thereof, and a use thereof; the structure of said phthalazinone compound is as represented by formula I; the compound of said formula I is targeted to a viral nucleocapsid; it can inhibit the replication of a virus by means of interference of the viral nucleocapsid, has a potent activity for inhibiting HBV DNA replication and a good liver targeting, can stably exist and enrich in the liver, and is a new and effective anti-HBV inhibitor.