公开(公告)号：US20130017975A1

公开(公告)日：2013-01-17

申请号：US13636782

申请日：2011-03-22

申请人： Young Hwa Chung ,  Neung Hwa Park ,  Eun Sil Yu ,  Young-Joo Lee ,  Jeong A Kim ,  Dan-Bi Lee ,  Sae-Hwan Lee ,  Jong-Eun Lee

发明人： Young Hwa Chung ,  Neung Hwa Park ,  Eun Sil Yu ,  Young-Joo Lee ,  Jeong A Kim ,  Dan-Bi Lee ,  Sae-Hwan Lee ,  Jong-Eun Lee

IPC分类号： C40B30/04 ,  C40B40/06 ,  C12Q1/68 ,  C07H21/04

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/156

摘要： Single nucleotide polymorphisms (SNP) for predicting prognosis of hepatocellular carcinoma after curative surgical resection are provided. The SNPs have a significant correlation with an over-expression of MTA1 which is useful prognostic factor for prediction of prognosis or poor survival after curative surgical resection of hepatocellular carcinoma. Therefore, the SNPs can be used in developing micro-arrays or test kits for prediction of the prognosis of hepatocellular carcinoma, and in screening drugs to improve poor prognosis of hepatocellular carcinoma after curative surgical resection.

摘要翻译： 提供单核苷酸多态性（SNP），用于预测治疗性手术切除后肝细胞癌的预后。 单核苷酸多态性与MTA1的过表达具有显着相关性，MTA1对肝细胞癌治愈手术切除后预后的预后或生存率差是有用的预后因素。 因此，SNP可用于开发微阵列或测试试剂盒，用于预测肝细胞癌的预后，并可用于筛选药物以改善治愈性手术切除后肝细胞癌的预后不良。