公开(公告)号：US20120264727A1

公开(公告)日：2012-10-18

申请号：US13467019

申请日：2012-05-08

申请人： Young Lag CHO ,  Hye Jin HEO ,  Kyu Man OH ,  Hyang Sook LEE ,  Chul Soon PARK ,  Sang Eun CHAE ,  Joung Yul YUN ,  Hyun Jin KWON ,  Young Jae YANG ,  Dae Hyuck KANG ,  Yong Zu KIM ,  Sung Ho WOO ,  Tae Kyo PARK

发明人： Young Lag CHO ,  Hye Jin HEO ,  Kyu Man OH ,  Hyang Sook LEE ,  Chul Soon PARK ,  Sang Eun CHAE ,  Joung Yul YUN ,  Hyun Jin KWON ,  Young Jae YANG ,  Dae Hyuck KANG ,  Yong Zu KIM ,  Sung Ho WOO ,  Tae Kyo PARK

IPC分类号： A61K31/546 ,  A61P31/04 ,  C07D501/60

CPC分类号： C07D501/60 ,  C07D501/24 ,  C07D501/46

摘要： The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R1, and R2 are as same as defined in the description of the invention.The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient.According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.

摘要翻译： 本发明涉及由化学式1表示的新型头孢菌素衍生物。其中，X，Y，L，R 1和R 2与本发明的描述中所定义相同。 本发明还涉及药物抗生素组合物，其包含由化学式1表示的新型胞孢素衍生物，其前药，其水合物，其溶剂合物，其异构体或其药学上可接受的盐作为有效成分。 根据本发明，新型头孢菌素衍生物，其前体药物，其水合物，其溶剂化物，其异构体或其药学上可接受的盐作为有效成分，用于广谱抗生素抗性，低毒性，特别是革兰氏阴性 - 阴性细菌，其可用于具有强的抗微生物活性。