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公开(公告)号：US20060281740A1
公开(公告)日：2006-12-14
申请号：US11451179
申请日：2006-06-12
申请人： Yu-Hua Ji , Mathai Mammen , Craig Husfeld , Li Li , YongQi Mu , Aaron Kushner , Eric Stangeland , Trevor Mischki , Adam Hughes , Sarah Dunham
发明人： Yu-Hua Ji , Mathai Mammen , Craig Husfeld , Li Li , YongQi Mu , Aaron Kushner , Eric Stangeland , Trevor Mischki , Adam Hughes , Sarah Dunham
IPC分类号： C07D417/02 , C07D413/02 , C07D401/02 , C07D403/02 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4545 , A61K31/454
CPC分类号： C07D211/46 , C07D405/12 , C07D409/12 , C07D487/08
摘要： The invention provides compounds of formula I: wherein a, b, c, m, s, t, W, Z, Ar, R1, R2, R3, R6, and R7 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，m，s，t，w，Z，Ar，R 1，R 2， > 3 ，R 6和R 7如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US07728144B2
公开(公告)日：2010-06-01
申请号：US11451179
申请日：2006-06-12
申请人： Yu-Hua Ji , Mathai Mammen , Craig Husfeld , Li Li , YongQi Mu , Aaron Kushner , Eric Stangeland , Trevor Mischki , Adam Hughes , Sarah Dunham
发明人： Yu-Hua Ji , Mathai Mammen , Craig Husfeld , Li Li , YongQi Mu , Aaron Kushner , Eric Stangeland , Trevor Mischki , Adam Hughes , Sarah Dunham
IPC分类号： C07D211/08 , A61K31/44
CPC分类号： C07D211/46 , C07D405/12 , C07D409/12 , C07D487/08
摘要： The invention provides compounds of formula I: wherein a, b, c, m, s, t, W, Z, Ar, R1, R2, R3, R6, and R7 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，m，s，t，w，Z，Ar，R 1，R 2，R 3，R 6和R 7如说明书中所定义。 式I的化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US20060205775A1
公开(公告)日：2006-09-14
申请号：US11371512
申请日：2006-03-09
申请人： Yu-Hua Ji , Craig Husfeld , Li Li , Mathai Mammen , YongQi Mu , Eric Stangeland
发明人： Yu-Hua Ji , Craig Husfeld , Li Li , Mathai Mammen , YongQi Mu , Eric Stangeland
IPC分类号： A61K31/4545 , A61K31/454 , C07D401/02 , C07D403/02
CPC分类号： C07D405/14 , C07D211/62 , C07D401/12 , C07D409/14
摘要： The invention provides compounds of formula I: wherein a, b, c, d, n, R1, R2, R3, R6, R7, W, and A are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，n，R 1，R 2，R 3，R 7，R 7，W和A如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US20060205946A1
公开(公告)日：2006-09-14
申请号：US11372251
申请日：2006-03-09
申请人： Yu-Hua Ji , Craig Husfeld , Mathai Mammen , YongQi Mu , Eric Stangeland
发明人： Yu-Hua Ji , Craig Husfeld , Mathai Mammen , YongQi Mu , Eric Stangeland
IPC分类号： A61K31/496 , A61K31/454 , C07D403/02
CPC分类号： C07D211/58 , C07D211/46 , C07D211/62 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D487/08 , C07D487/10
摘要： The invention provides compounds of formula I: wherein a, b, c, d, f, W, Q, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，f，w，Q，Y，R 1，R 2和R 2， 3 如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US20050203131A1
公开(公告)日：2005-09-15
申请号：US11077345
申请日：2005-03-10
申请人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Eric Stangeland , Aaron Kushner , Craig Husfeld
发明人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Eric Stangeland , Aaron Kushner , Craig Husfeld
IPC分类号： A61K31/4545 , C07D211/60 , C07D211/62 , C07D41/02
CPC分类号： C07D211/62 , C07D211/60
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，m，n，p，r，R 1，R 2，R 3 R 4，R 5，R 5，R 6，R 7和W定义如上所述。 在规范中。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US07521041B2
公开(公告)日：2009-04-21
申请号：US11974318
申请日：2007-10-12
申请人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
发明人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
CPC分类号： C07D211/62 , A61K9/124 , A61K9/1623 , A61K9/1652 , A61K31/4545 , A61K45/06 , C07D401/12
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
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公开(公告)号：US20130172301A1
公开(公告)日：2013-07-04
申请号：US13592713
申请日：2012-08-23
申请人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
发明人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
IPC分类号： C07D211/62 , A61K45/06 , A61K31/4545
CPC分类号： C07D211/62 , A61K9/124 , A61K9/1623 , A61K9/1652 , A61K31/4545 , A61K45/06 , C07D401/12
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
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公开(公告)号：US20120190657A1
公开(公告)日：2012-07-26
申请号：US13438105
申请日：2012-04-03
申请人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
发明人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
IPC分类号： A61K31/4545 , A61P11/00 , A61K31/56
CPC分类号： C07D211/62 , A61K9/124 , A61K9/1623 , A61K9/1652 , A61K31/4545 , A61K45/06 , C07D401/12
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，m，n，p，s，t，W，Ar1，R1，R2，R3，R4，R6，R7和R8如 规范。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US20100249421A1
公开(公告)日：2010-09-30
申请号：US12814629
申请日：2010-06-14
申请人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
发明人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
IPC分类号： C07D401/12
CPC分类号： C07D211/62 , A61K9/124 , A61K9/1623 , A61K9/1652 , A61K31/4545 , A61K45/06 , C07D401/12
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，m，n，p，s，t，W，Ar1，R1，R2，R3，R4，R6，R7和R8如 规范。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US20080071088A1
公开(公告)日：2008-03-20
申请号：US11899181
申请日：2007-09-05
申请人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
发明人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
IPC分类号： C07D401/12
CPC分类号： C07D211/62 , A61K9/124 , A61K9/1623 , A61K9/1652 , A61K31/4545 , A61K45/06 , C07D401/12
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
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