公开(公告)号：US11478496B2

公开(公告)日：2022-10-25

申请号：US17697306

申请日：2022-03-17

申请人： Yuk-Ching Tse-Dinh ,  Yuan Liu ,  Irina Agoulnik

发明人： Yuk-Ching Tse-Dinh ,  Yuan Liu ,  Irina Agoulnik

IPC分类号： A61K31/7048 ,  A61P35/00 ,  A61K45/06 ,  A61K31/546 ,  A61K31/4365 ,  A61K31/593

摘要： The present invention provides compounds, compositions and methods for the treatment of prostate cancers, preferably, advanced prostate cancers. The subject invention also provides compounds, compositions and methods for preventing/slowing down/reducing the progress and proliferation of prostate cancer cells. The subject invention further provides compounds, compositions and methods for inhibiting DNA repair within cancer cells to slow tumor growth, preferably, by inhibiting BER capacity, including pol β and LIG I.

公开(公告)号：US11304969B2

公开(公告)日：2022-04-19

申请号：US16751696

申请日：2020-01-24

申请人： Yuk-Ching Tse-Dinh ,  Yuan Liu ,  Irina Agoulnik

发明人： Yuk-Ching Tse-Dinh ,  Yuan Liu ,  Irina Agoulnik

IPC分类号： A61K31/7048 ,  A61P35/00 ,  A61K45/06 ,  A61K31/546 ,  A61K31/4365 ,  A61K31/593

摘要： The present invention provides compounds, compositions and methods for the treatment of prostate cancers, preferably, advanced prostate cancers. The subject invention also provides compounds, compositions and methods for preventing/slowing down/reducing the progress and proliferation of prostate cancer cells. The subject invention further provides compounds, compositions and methods for inhibiting DNA repair within cancer cells to slow tumor growth, preferably, by inhibiting BER capacity, including pol β and LIG I.

公开(公告)号：US11839621B2

公开(公告)日：2023-12-12

申请号：US18048504

申请日：2022-10-21

申请人： Yuk-Ching Tse-Dinh ,  Yuan Liu ,  Irina Agoulnik

发明人： Yuk-Ching Tse-Dinh ,  Yuan Liu ,  Irina Agoulnik

IPC分类号： A61K31/7048 ,  A61P35/00 ,  A61K45/06 ,  A61K31/546 ,  A61K31/4365 ,  A61K31/593

CPC分类号： A61K31/7048 ,  A61P35/00 ,  A61K31/4365 ,  A61K31/546 ,  A61K31/593 ,  A61K45/06

摘要： The present invention provides compounds, compositions, and methods for the treatment of prostate cancers, preferably, advanced prostate cancers. The subject invention also provides compounds, compositions, and methods for preventing/slowing down/reducing the progress and proliferation of prostate cancer cells. The subject invention further provides compounds, compositions, and methods for inhibiting DNA repair within cancer cells to slow tumor growth, preferably, by inhibiting BER capacity, including pol β and LIG I.