公开(公告)号：US5698697A

公开(公告)日：1997-12-16

申请号：US683370

申请日：1996-07-18

申请人： Yuki Takuma ,  Yuzo Kasuga ,  Takeki Miyazaki ,  Yuji Mizuho ,  Ken Okamoto

发明人： Yuki Takuma ,  Yuzo Kasuga ,  Takeki Miyazaki ,  Yuji Mizuho ,  Ken Okamoto

IPC分类号： C07D241/04

CPC分类号： C07D241/04

摘要： 2-Cyanopiperazine represented by the following formula (1): ##STR1## or a salt thereof. The 2-cyanopiperazine can be produced by reacting a 2-halogenoacrylonitrile with ethylenediamine or by reacting a 2,3-dihalogenopropionitrile with ethylenediamine. The 2-cyanopiperazine is useful as an intermediate for medicaments, agricultural chemicals, etc., and optically active N-tert-butyl-2-piperazine carboxamide, which is useful as an intermediate in preparation of the HIV protease inhibitor indinavir, can be easily produced using the 2-cyanopiperazine.

摘要翻译： 由下式（1）表示的2-氰基哌嗪：其中（1）或其盐。 2-氰基哌嗪可以通过使2-卤代丙烯腈与乙二胺反应或通过使2,3-二卤代丙腈与乙二胺反应来制备。 2-氰基哌嗪可用作药物，农药等的中间体，可用于制备HIV蛋白酶抑制剂茚地那韦的中间体的光学活性N-叔丁基-2-哌嗪甲酰胺可以容易地 使用2-氰基哌嗪生产。