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公开(公告)号：US20110160432A1
公开(公告)日：2011-06-30
申请号：US13054229
申请日：2008-07-15
申请人： Yusong Chen , Shu Li , Risheng Wang , Qiang Liang , Zheng Zeng , Xiaohong Qian , Dong Cao , Huimin Liang
发明人： Yusong Chen , Shu Li , Risheng Wang , Qiang Liang , Zheng Zeng , Xiaohong Qian , Dong Cao , Huimin Liang
CPC分类号： C07K7/08 , A61K38/00 , C07K14/4716
摘要： Disclosed are two myocardial peptides, whose amino acid sequences are Trp-Ser-Asn-Val-Leu-Arg-Gly-Met-Gly-Gly-Ala-Phe and Lys-Gly-Ala-Trp-Ser-Asn-Val-Leu-Arg-Gly-Met-Gly-Gly-Ala-Phe respectively, wherein the latter can be obtained by extracting from myocardial peptides solution. The myocardial peptides can be used in the produce of a medicament for preventing and/or treating myocardial ischemia.
摘要翻译： 公开了两种心肌肽，其氨基酸序列是Trp-Ser-Asn-Val-Leu-Arg-Gly-Met-Gly-Gly-Ala-Phe和Lys-Gly-Ala-Trp-Ser-Asn-Val-Leu -Arg-Gly-Met-Gly-Gly-Ala-Phe，其中后者可以通过从心肌肽溶液中提取获得。 心肌肽可用于产生用于预防和/或治疗心肌缺血的药物。
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公开(公告)号：US08940865B2
公开(公告)日：2015-01-27
申请号：US13054229
申请日：2008-07-15
申请人： Yusong Chen , Shu Li , Risheng Wang , Qiang Liang , Zheng Zeng , Xiaohong Qian , Dong Cao , Huimin Liang
发明人： Yusong Chen , Shu Li , Risheng Wang , Qiang Liang , Zheng Zeng , Xiaohong Qian , Dong Cao , Huimin Liang
IPC分类号： C07K7/00
CPC分类号： C07K7/08 , A61K38/00 , C07K14/4716
摘要： Disclosed are two myocardial peptides, whose amino acid sequences are Trp-Ser-Asn-Val-Leu-Arg-Gly-Met-Gly-Gly-Ala-Phe and Lys-Gly-Ala-Trp-Ser-Asn-Val-Leu-Arg-Gly-Met-Gly-Gly-Ala-Phe respectively, wherein the latter can be obtained by extracting from myocardial peptides solution. The myocardial peptides can be used in the produce of a medicament for preventing and/or treating myocardial ischemia.
摘要翻译： 公开了两种心肌肽，其氨基酸序列是Trp-Ser-Asn-Val-Leu-Arg-Gly-Met-Gly-Gly-Ala-Phe和Lys-Gly-Ala-Trp-Ser-Asn-Val-Leu -Arg-Gly-Met-Gly-Gly-Ala-Phe，其中后者可以通过从心肌肽溶液中提取获得。 心肌肽可用于产生用于预防和/或治疗心肌缺血的药物。
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公开(公告)号：US20070117745A1
公开(公告)日：2007-05-24
申请号：US10567286
申请日：2004-02-23
申请人： Yusong Chen , Shu Li
发明人： Yusong Chen , Shu Li
IPC分类号： A61K38/17 , A61K31/7012 , C07K14/705
CPC分类号： C07K14/4716 , A61K38/00
摘要： The present invention relates to a cardio myopeptidin which is isolated from the hearts of non-human healthy mammals. The molecular weight of the cardio myopeptidin is less than 10000 Dalton, the peptide content thereof being 75%˜90%, the free amino acid content 6%˜15%, the ribonucleic acid content less than 2%, and the deoxyribonucleic acid content less than 7.5%. The present invention further provides a method of producing the cardio myopeptidin and the use thereof in producing pharmaceuticals for treating cardiac disorders, specifically the use in producing pharmaceuticals for treating myocardial ischemic and reperfusion injury. The cardio myopeptidin of the present invention can work directly on myocytes, promoting the repair of injuries caused by various reasons, and providing a new way to relieve ischemic and reperfusion injury, and to promote the repair of injured myocardium.
摘要翻译： 本发明涉及从非人健康哺乳动物的心脏中分离的心脏肌肽。 心肌肌肽的分子量小于10000道尔顿，肽含量为75％〜90％，游离氨基酸含量为6％〜15％，核糖核酸含量低于2％，脱氧核糖核酸含量较少 超过7.5％。 本发明还提供了生产心肌肌肽的方法及其在制备用于治疗心脏病的药物中的用途，特别是用于制备治疗心肌缺血和再灌注损伤的药物的用途。 本发明的心脏肌肽可以直接在肌细胞上起作用，促进由各种原因造成的损伤的修复，并提供减轻缺血和再灌注损伤的新方法，并促进损伤心肌的修复。
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公开(公告)号：US07427663B2
公开(公告)日：2008-09-23
申请号：US10567286
申请日：2004-02-23
申请人： Yusong Chen , Shu Li
发明人： Yusong Chen , Shu Li
IPC分类号： C07K14/00
CPC分类号： C07K14/4716 , A61K38/00
摘要： The present invention relates to a cardio myopeptidin which is isolated from the hearts of non-human healthy mammals. The molecular weight of the cardio myopeptidin is less than 10000 Dalton, the peptide content thereof being 75%˜90%, the free amino acid content 6%˜15%, the ribonucleic acid content less than 2%, and the deoxyribonucleic acid content less than 7.5%. The present invention further provides a method of producing the cardio myopeptidin and the use thereof in producing pharmaceuticals for treating cardiac disorders, specifically the use in producing pharmaceuticals for treating myocardial ischemic and reperfusion injury. The cardio myopeptidin of the present invention can work directly on myocytes, promoting the repair of injuries caused by various reasons, and providing a new way to relieve ischemic and reperfusion injury, and to promote the repair of injured myocardium.
摘要翻译： 本发明涉及从非人健康哺乳动物的心脏中分离的心脏肌肽。 心肌肌肽的分子量小于10000道尔顿，肽含量为75％〜90％，游离氨基酸含量为6％〜15％，核糖核酸含量低于2％，脱氧核糖核酸含量较少 超过7.5％。 本发明还提供了生产心肌肌肽的方法及其在制备用于治疗心脏病的药物中的用途，特别是用于制备治疗心肌缺血和再灌注损伤的药物的用途。 本发明的心脏肌肽可以直接在肌细胞上起作用，促进由各种原因造成的损伤的修复，并提供减轻缺血和再灌注损伤的新方法，并促进损伤心肌的修复。
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