公开(公告)号：US20060093670A1

公开(公告)日：2006-05-04

申请号：US10516122

申请日：2003-06-09

申请人： Yutaka Mizushima ,  Yukie Takagi ,  Tomomi Hagi ,  Toshiyuki Ikoma

发明人： Yutaka Mizushima ,  Yukie Takagi ,  Tomomi Hagi ,  Toshiyuki Ikoma

IPC分类号： A61K38/39 ,  A61K31/737 ,  A61K9/22

CPC分类号： A61K9/0024 ,  A61K9/143 ,  A61K9/1611

摘要： The present invention provides a sustained-release composition by which a sustained-release effect can be obtained for a long time when injecting microparticles of the composition in an amount that can be subcutaneously or intramuscularly injected to a human with ease and without pain. The composition comprises porous hydroxyapatite microparticles having pores embolized by filling the pores in the microparticles with a biologically active drug, a human serum protein, and a mucopolysaccharide, and adding a divalent metal ion. Alternatively, the composition comprises porous hydroxyapatite microparticles having pores embolized in the outer layer by filling the pores in the microparticles with a biologically active drug, a human serum protein, and a water-soluble calcium salt one after another or at one time, and then adding sodium carbonate, sodium hydrogen carbonate, or an aqueous carbonate ion solution.

摘要翻译： 本发明提供了一种持续释放组合物，通过该缓释组合物，将组合物的微粒注入可以皮下或肌肉内注射的人容易且无疼痛的长时间下，可以获得持续释放作用。 该组合物包含通过用生物活性药物，人血清蛋白质和粘多糖填充微粒中的孔而堵塞孔的多孔羟基磷灰石微粒，并加入二价金属离子。 或者，组合物包含多孔羟基磷灰石微粒，其通过用生物活性药物，人血清蛋白和水溶性钙盐一次又一次或一次填充微粒中的孔，在外层中堵塞孔，然后 加入碳酸钠，碳酸氢钠或碳酸氢钠水溶液。