公开(公告)号：US20090269385A1

公开(公告)日：2009-10-29

申请号：US12432826

申请日：2009-04-30

申请人： Yuval ZUBERY ,  Arie GOLDLUST ,  Thomas BAYER ,  Eran NIR

发明人： Yuval ZUBERY ,  Arie GOLDLUST ,  Thomas BAYER ,  Eran NIR

IPC分类号： A61F2/00 ,  A61K38/18 ,  A61K38/00 ,  A61K31/726 ,  A61K31/727 ,  A61K33/42 ,  A61K31/7088 ,  A61K31/722 ,  A61K35/00 ,  A61K35/32 ,  A61K35/30

CPC分类号： A61L27/56 ,  A61L27/48 ,  C08L89/06

摘要： Collagen based matrices cross-linked by a reducing sugar(s) are used for preparing composite matrices, implants and scaffolds. The composite matrices may have at least two layers including reducing sugar cross-linked collagen matrices of different densities. The composite matrices may be used in bone regeneration and/or augmentation applications. Scaffolds including glycated and/or reducing sugar cross-linked collagen exhibit improved support for cell proliferation and/or growth and/or differentiation. The denser collagen matrix of the composite matrices may have a dual effect initially functioning as a cell barrier and later functioning as an ossification supporting layer. The composite matrices, implants and scaffolds may be prepared using different collagen types and collagen mixtures and by cross-linking the collagen(s) using a reducing sugar or a mixture of reducing sugars. The composite matrices, implants and scaffolds may include additives and/or living cells.