公开(公告)号：US20170151256A1

公开(公告)日：2017-06-01

申请号：US15429409

申请日：2017-02-10

申请人： ZERIA PHARMACEUTICAL CO., LTD.

发明人： Koji YOSHINAGA ,  Daisuke KAWASAKI ,  Yutaka EMORI

IPC分类号： A61K31/551 ,  A61K31/7068 ,  A61K31/513 ,  A61K9/00

CPC分类号： A61K31/551 ,  A61K9/0053 ,  A61K31/513 ,  A61K31/7068 ,  A61K45/06 ,  C07D243/12 ,  A61K2300/00

摘要： To provide a pharmaceutical agent or an antitumor agent useful for the treatment and/or prevention of gastrointestinal cancer, leukemia, pituitary tumor, small cell lung cancer, thyroid cancer, and neuroastrocytoma. The antitumor agent containing, as an active ingredient, a 1,5-benzodiazepine derivative represented by the following formula (1): (wherein R1 represents a C1-6 alkyl group; R2 represents a phenyl group or a cyclohexyl group; and Y represents a single bond or a C1-4 alkylene group) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20180318314A1

公开(公告)日：2018-11-08

申请号：US16032322

申请日：2018-07-11

申请人： ZERIA PHARMACEUTICAL CO., LTD.

发明人： Koji YOSHINAGA ,  Daisuki Kawasaki ,  Yutaka Emori

IPC分类号： A61K31/551 ,  A61K31/7068 ,  A61K31/513 ,  C07D243/12 ,  A61K45/06 ,  A61K9/00

CPC分类号： A61K31/551 ,  A61K9/0053 ,  A61K31/513 ,  A61K31/7068 ,  A61K45/06 ,  C07D243/12 ,  A61K2300/00

摘要： To provide a pharmaceutical agent or an antitumor agent useful for the treatment and/or prevention of gastrointestinal cancer, leukemia, pituitary tumor, small cell lung cancer, thyroid cancer, and neuroastrocytoma. The antitumor agent containing, as an active ingredient, a 1,5-benzodiazepine derivative represented by the following formula (1): (wherein R1 represents a C1-6 alkyl group; R2 represents a phenyl group or a cyclohexyl group; and Y represents a single bond or a C1-4 alkylene group) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20150038495A1

公开(公告)日：2015-02-05

申请号：US14495047

申请日：2014-09-24

申请人： Zeria Pharmaceutical Co., Ltd.

发明人： Koji YOSHINAGA ,  Hiroki Hamano ,  Takayuki Hori

IPC分类号： C07D243/12 ,  A61K45/06 ,  A61K31/551

CPC分类号： C07D243/12 ,  A61K31/551 ,  A61K45/06

摘要： To provide a cancer pain therapeutic and/or prophylactic agent which can be administered to a patient for a long period of time from the early stage to the final stage of the cancer pain therapy, instead of conventional non-opioid analgesic agents or opioid analgesic agents.The cancer pain therapeutic and/or prophylactic agent containing, as an active ingredient, a 1,5-benzodiazepine derivative represented by formula (1):(wherein R1 represents a C1-6 alkyl group, R2 represents a phenyl group or a cyclohexyl group, and Y represents a single bond or a C1-4 an alkylene group) or a pharmaceutically acceptable salt thereof.

摘要翻译： 为了提供可以从癌症疼痛治疗的早期阶段到最终阶段长期施用于患者的癌症疼痛治疗和/或预防剂，而不是常规的非阿片类镇痛药或阿片样镇痛剂 。 作为活性成分含有式（1）表示的1,5-苯并二氮杂衍生物的癌症疼痛治疗和/或预防剂：其中，R1表示C1-6烷基，R2表示苯基或环己基 ，Y表示单键或C 1-4亚烷基）或其药学上可接受的盐。