公开(公告)号：US20240300911A1

公开(公告)日：2024-09-12

申请号：US18261480

申请日：2022-01-10

申请人： ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. ,  Zhejiang Huahai LiCheng Pharmaceutical Co., Ltd.

发明人： Jian ZHANG ,  Jichao WANG ,  Zheng HAN ,  Yihong XU ,  Jiaxing HU ,  Wenfeng HUANG ,  Yongjun JIN

IPC分类号： C07D307/81

CPC分类号： C07D307/81

摘要： The present invention provides a purification method for citalopram or S-citalopram or salts thereof, comprising the following steps: using a washing solution to treat a solution consisting of citalopram and a water-immiscible organic solvent and carrying out separation to obtain an organic layer containing citalopram, or using a washing solution to treat a solution consisting of S-citalopram and a water-immiscible organic solvent and carrying out separation to obtain an organic layer containing S-citalopram; and then, taking the organic layer and carrying out further separation to obtain citalopram or S-citalopram, or adding acid to form a salt and carrying out further separation to obtain an acid salt of citalopram or S-citalopram. The purification method provided by the present invention is simple in operation and high in impurity removal rate.