公开(公告)号：US10774350B2

公开(公告)日：2020-09-15

申请号：US16016813

申请日：2018-06-25

申请人： ZHEJIANG NHU COMPANY LTD. ,  ZHEJIANG UNIVERSITY ,  HEILONGJIANG NHU BIOTECHNOLOGY COMPANY LTD. ,  SHANGYU NHU BIOLOGICAL CHEMICAL CO., LTD.

发明人： Shenfeng Yuan ,  Hongwei Yu ,  Zhaofeng Chen ,  Yongqiang Zhu ,  Yi Min ,  Yong Li ,  Baishan Hu ,  Guisheng Qiu ,  Kai Yu

IPC分类号： C12P7/66

摘要： The present application relates to a method for fermentative production of oxidized coenzyme Q10 and high-content oxidized coenzyme Q10 prepared therefrom. For the method for fermentative production of oxidized coenzyme Q10, in a fermentation process of a production strain, the oxidation-reduction potential (ORP) of a fermentation broth is controlled to be −50 to 300 Mv, and preferably the oxidation-reduction potential (ORP) of the fermentation broth is controlled to be 50 to 200 mV. By controlling the ORP of the fermentation broth, the method for fermentative production of oxidized coenzyme Q10 enables the oxidized coenzyme Q10 content in the coenzyme Q10 produced by microorganisms to reach 96% or more, and the product is substantially composed of a single component, which makes post-treatment more convenient. Oxidized coenzyme Q10 is more stable than reduced coenzyme Q10, and as compared with the coenzyme Q10 obtained by fermentative production in the prior art, high-content oxidized coenzyme Q10 degrades in a less amount in organisms. In addition, the fermentation method of the present application has a high potency.