公开(公告)号：US20240350702A1

公开(公告)日：2024-10-24

申请号：US18757611

申请日：2024-06-28

申请人： ZHEJIANG UNIVERSITY ,  SHAOXING RESEARCH INSTITUTE OF ZHEJIANG UNIVERSITY

发明人： Changyou GAO ,  Jie WANG ,  Xiaofei DONG

IPC分类号： A61L26/00

CPC分类号： A61L26/0014 ,  A61L26/0023 ,  A61L26/008 ,  A61L2300/404

摘要： An antibacterial dressing for promoting scarless wound healing and a method for preparing the same provided. The dressing consists of 0.05-0.1 part by weight of hyperbranched polylysine anti-scar compound, 0.1-2.0 parts by weight of carbomer, 1-10 parts by weight of a thickener, 2-12 parts by weight of a humectant, 60-90 parts by weight of water and 1-15 parts by weight of a plant extract. The hyperbranched polylysine and the anti-scar drug are grafted and synthesized into a new compound, so that the antibacterial activity of the hyperbranched polylysine and the ability of the anti-scar drug to inhibit the scar formation of the wound are retained; meanwhile, a film with good air permeability and moisture retention can be formed on the skin surface through the film forming agent, so that the wound surface is kept in a moist environment, which is beneficial to wound healing and does not generate scars.

公开(公告)号：US20220272956A1

公开(公告)日：2022-09-01

申请号：US17622770

申请日：2020-06-23

申请人： ZHEJIANG UNIVERSITY

发明人： Mingying YANG ,  Jie WANG ,  Yuyin CHEN ,  Ying ZHANG

IPC分类号： A01K67/04 ,  A23K20/147 ,  C09K11/02 ,  C09K11/77 ,  B82Y99/00

摘要： Disclosed is a method for constructing fluorescent Bombyx Mori silkworm silk irradiated by near-infrared light and its products, comprising: (1) preparing upconversion nanoparticles, and performing surface modification with concanavalin to obtain modified upconversion nanoparticles; (2) uniformly dispersing the modified upconversion nanoparticles in water to formulate an aqueous solution of the upconversion nanoparticles, (3) picking mature mulberry leaves, immersing the mulberry leaves in the aqueous solution system of the nanoparticles, leaching water, and naturally drying the mulberry leaves; (4) after silkworms have grown for a set time, feeding the treated mulberry leaves to the silkworms until the silkworms spin silk cocoons; and (5) collecting the silk, so as to obtain mulberry silk that fluoresces under near-infrared light. The present invention selects upconversion nanoparticles capable of emitting fluorescence under the irradiation of near-infrared light which has stronger penetration, thus has better application in deep tissue imaging.

公开(公告)号：US20220273580A1

公开(公告)日：2022-09-01

申请号：US17622759

申请日：2020-06-23

申请人： ZHEJIANG UNIVERSITY

发明人： Mingying YANG ,  Jie WANG ,  Yuyin CHEN

IPC分类号： A61K9/51 ,  A61K31/704

摘要： The present invention discloses a method for preparing a drug-loaded silk fibroin nanocapsule, and a prepared drug-loaded silk fibroin nanocapsule. The method comprises: performing a coating treatment of applying alternating layers of silk fibroin and 3-aminopropyl triethoxysilane on functionally modified polystyrene microspheres, to ultimately obtain a multi-layer-structured coated polystyrene composite with a negative or positive potential, and finally removing the functionally modified polystyrene template with a template-removing reagent, to obtain a drug-loaded silk fibroin nanocapsule. The functionally modified polystyrene microspheres are positive potential microspheres, and silk fibroin is used for the first coating. In the case of negative potential microspheres, 3-aminopropyl triethoxysilane is used for the first treatment. The process is simple and has wide applicability. The dimensions of the prepared microcapsule can be controlled at the nanometer level, so that the microcapsule can more effectively transport a drug to the interior of a cell to come into play.