公开(公告)号：US20190255076A1

公开(公告)日：2019-08-22

申请号：US16298818

申请日：2019-03-11

申请人： ZebraPeutics Inc.

发明人： Xiao-Yan Wen ,  R. Loch MacDonald ,  Andrew Baker ,  Tom A. Schweizer

IPC分类号： A61K31/585 ,  A61P9/00 ,  A61P9/14 ,  A61K31/58 ,  A61K31/567 ,  C07J1/00 ,  A61K31/4422 ,  A61K31/366 ,  A61K31/357 ,  C07J73/00 ,  A61K31/4545

摘要： The described invention relates to small molecule therapeutic compounds capable of reducing the incidence of intracerebral hemorrhage and brain microhemorrhages identified using zebrafish and mouse models of intracerebral hemorrhage and brain microhemorrhages.

公开(公告)号：US20230174571A1

公开(公告)日：2023-06-08

申请号：US17920169

申请日：2021-04-20

申请人： Zebrapeutics Inc.

发明人： Xiao-Yan Wen ,  Raymond John Andersen ,  Alice Low-Fung Mui ,  Yuanyuan Zhao

IPC分类号： C07J69/00 ,  C07J71/00 ,  A61P29/00 ,  A61P1/16 ,  A61P1/04 ,  A61P37/08 ,  A61P35/00

CPC分类号： C07J69/00 ,  C07J71/0068 ,  C07J71/0052 ,  A61P29/00 ,  A61P1/16 ,  A61P1/04 ,  A61P37/08 ,  A61P35/00

摘要： Provided are compounds of Formula I and pharmaceutically acceptable salt, solvate and/or derivative thereof. Further, provided are methods of treating a disease, disorder or condition mediated or treatable by activation of SHIP1 comprising administering a compound of Formula I or a pharmaceutically acceptable salt, solvate or derivative thereof. The compound of Formula I or a pharmaceutically acceptable salt, solvate or derivative thereof may be used in the treatment of SHIP1 mediated disease, disorder or conditions including inflammatory bowel disease (IBD), Crohn' disease, ulcerative colitis, multiple myeloma, liver injury, acute hepatitis and severe sepsis.