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公开(公告)号：US10550109B2
公开(公告)日：2020-02-04
申请号：US16300301
申请日：2017-05-12
发明人： Yinglu Jiao , Handa Li , Boyu Wang , Luning Huang , Xi Chen , Hong Gu
IPC分类号： C07D409/14
摘要： Disclosed are a crystal form of brexpiprazole and a preparation method therefor. The X-ray powder diffraction pattern, which is detected with Cu—Kα radiation, of the crystal form of brexpiprazole has characteristic peaks at the positions where 2θ is about 9.1±0.2, 15.2±0.2, 15.7±0.2, 17.6±0.2, 18.1±0.2, 24.4±0.2. The crystal form I of brexpiprazole has a high purity, good stability and good reproducibility, and is suitable for industrial production.
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公开(公告)号：US12084425B2
公开(公告)日：2024-09-10
申请号：US17295843
申请日：2019-10-12
IPC分类号： C07D307/87
CPC分类号： C07D307/87 , C07B2200/13
摘要： Provided herein is a method for preparing an Escitalopram bis-hydroxynaphtoate ((S)-(+)-1-(3-(-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydro-5-cyanisob enzofuranone) crystal form A. Said method is ecofriendly and non pollutive, and the obtained Escitalopram bis-hydroxynaphtoate crystal form A is highly pure and easy to reproduce.
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公开(公告)号：US11014885B2
公开(公告)日：2021-05-25
申请号：US16618896
申请日：2018-06-05
IPC分类号： C07D211/32 , C07C63/46
摘要： Disclosed is a new method for preparing a donepezil pamoate (1-benzyl-4-[(5,6-dimethoxyindan-2-one)methyl]piperidine pamoate). The donepezil pamoate prepared by using the method has a high purity and a good flowability.
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公开(公告)号：US11168063B2
公开(公告)日：2021-11-09
申请号：US16618898
申请日：2018-06-05
IPC分类号： C07D307/87
摘要： The present invention relates to a new preparation method for escitalopram pamoate ((S)-(+)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-cyanoisob enzofuran pamoate), wherein the method is environmentally friendly and pollution-free, and the escitalopram pamoate prepared by means of the method has a high purity and a good repeatability.
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公开(公告)号：US11365178B2
公开(公告)日：2022-06-21
申请号：US16957685
申请日：2018-12-25
发明人： Hu Su , Xiaowen Guo , Yukun Liang , Kaiqiang Shi , Jintao Yang , Kang He , Anping Tao , Luning Huang , Jianguo An , Xi Chen , Hong Gu
IPC分类号： C07D239/54
摘要： The present invention relates to a method for preparing an intermediate (Formula IV) of sodium elagolix. The intermediate is prepared by the following route. The method has advantages of simple and safe operation, high yield, less environmental pollution, good economic effect and suitability for industrial production, wherein R represents C1-C4 substituted or unsubstituted benzyl or allyl.
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公开(公告)号：US20200369625A1
公开(公告)日：2020-11-26
申请号：US16957685
申请日：2018-12-25
发明人： Hu Su , Xiaowen Guo , Yukun Liang , Kaiqiang Shi , Jintao Yang , Kang He , Anping Tao , Luning Huang , Jianguo An , Xi Chen , Hong Gu
IPC分类号： C07D239/54
摘要： The present invention relates to a method for preparing an intermediate (Formula IV) of sodium elagolix. The intermediate is prepared by the following route. The method has advantages of simple and safe operation, high yield, less environmental pollution, good economic effect and suitability for industrial production, wherein R represents C1-C4 substituted or unsubstituted benzyl or allyl.
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