公开(公告)号：US20140206762A1

公开(公告)日：2014-07-24

申请号：US13745740

申请日：2013-01-18

申请人： Zheng Tao Han ,  Hung-Fong Chen

发明人： Zheng Tao Han ,  Hung-Fong Chen

IPC分类号： A61K31/215 ,  A61K45/06

CPC分类号： A61K31/215 ,  A61K31/14 ,  A61K31/23 ,  A61K31/573 ,  A61K31/60 ,  A61K33/06 ,  A61K45/06 ,  A61K2300/00

摘要： Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms or sequelae of disease. Chronic and acute conditions may be due to viral infections such as HIV and AIDS, neoplastic diseases stroke, kidney disease, urinary incontinence, autoimmune disorders, Parkinson's disease, prostate hypertrophy, aging, or the treatment of such diseases. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools against acute and chronic conditions in mammalian subjects.

摘要翻译： 提供含有佛波醇酯或佛波醇酯衍生物的方法和组合物用于治疗慢性和急性病症。 这种情况可能是由疾病，症状或后遗症引起的。 慢性和急性病症可能是由于艾滋病毒和艾滋病，肿瘤性疾病中风，肾脏疾病，尿失禁，自身免疫性疾病，帕金森病，前列腺肥大，衰老或这些疾病的治疗等病毒感染。 提供了另外的组合物和方法，其使用佛波醇酯或衍生化合物与至少一种另外的试剂组合，以产生针对哺乳动物受试者的急性和慢性病症的更有效的治疗工具。

公开(公告)号：US11564901B2

公开(公告)日：2023-01-31

申请号：US13745740

申请日：2013-01-18

申请人： Zheng Tao Han ,  Hung-Fong Chen

发明人： Zheng Tao Han ,  Hung-Fong Chen

IPC分类号： A61K31/215 ,  A61K45/06 ,  A61K31/23 ,  A61K31/573 ,  A61K31/60 ,  A61K31/14 ,  A61K33/06

摘要： Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms or sequelae of disease. Chronic and acute conditions may be due to viral infections such as HIV and AIDS, neoplastic diseases stroke, kidney disease, urinary incontinence, autoimmune disorders, Parkinson's disease, prostate hypertrophy, aging, or the treatment of such diseases. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools against acute and chronic conditions in mammalian subjects.

公开(公告)号：US20160106698A9

公开(公告)日：2016-04-21

申请号：US13745740

申请日：2013-01-18

申请人： Zheng Tao Han ,  Hung-Fong Chen

发明人： Zheng Tao Han ,  Hung-Fong Chen

IPC分类号： A61K31/215 ,  A61K45/06

CPC分类号： A61K31/215 ,  A61K31/14 ,  A61K31/23 ,  A61K31/573 ,  A61K31/60 ,  A61K33/06 ,  A61K45/06 ,  A61K2300/00

摘要： Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms or sequelae of disease. Chronic and acute conditions may be due to viral infections such as HIV and AIDS, neoplastic diseases stroke, kidney disease, urinary incontinence, autoimmune disorders, Parkinson's disease, prostate hypertrophy, aging, or the treatment of such diseases. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools against acute and chronic conditions in mammalian subjects.

公开(公告)号：US20080226589A1

公开(公告)日：2008-09-18

申请号：US12023753

申请日：2008-01-31

申请人： Zheng Tao Han

发明人： Zheng Tao Han

IPC分类号： A61K38/20 ,  A61K31/225 ,  A61K38/45 ,  A61K31/7042 ,  A61K31/704 ,  A61K31/52 ,  A61K31/4196 ,  A61K38/21 ,  A61K31/56 ,  A61P31/18 ,  A61P35/00 ,  A61K31/517 ,  A61K31/496 ,  A61K39/395 ,  A61K38/14 ,  A61K31/352 ,  A61K33/42 ,  A61K31/7076 ,  A61K31/66

CPC分类号： C07C69/22 ,  A61K31/225 ,  A61K31/23 ,  A61K31/55 ,  A61K31/573 ,  A61K31/60 ,  A61K31/606 ,  A61K31/618 ,  A61K45/06 ,  A61P31/18 ,  A61P35/00 ,  A61P35/02 ,  C07C69/013 ,  C07C69/33 ,  C07C2603/40 ,  Y02A50/475 ,  Y02A50/481 ,  Y02A50/492

摘要： Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of cytopathic diseases. Cytopathic diseases may be caused by a variety means such as viral infections like HIV and AIDS, or the development of neoplasms in a mammalian subject. The methods and compositions of the invention are effective for inhibiting de novo HIV infections upregulating viral expression from latent provirus, inhibiting HIV-induced cytopathic effects, down regulating the HIV receptor, increasing Th1 cytokine expression, decreasing Th2 cytokine expression, increasing ERK phosphorylation, inducing apoptosis in malignant cells, inducing remission, maintaining remission, as chemotherapeutic agents, as well as for decreasing symptoms of cytopathic diseases and opportunistic infections that may accompany such diseases. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent such as those used in HAART protocols, therapeutic agents used to treat opportunistic infections due to HIV, or chemotherapeutic agents to yield more effective treatment tools against cytopathic diseases in mammalian subjects.

摘要翻译： 提供含有佛波醇酯或佛波醇酯衍生物的方法和组合物用于治疗细菌性疾病。 细胞致病性疾病可能是由诸如HIV和AIDS之类的病毒感染或哺乳动物受试者的肿瘤发展等多种手段引起的。 本发明的方法和组合物对于抑制从潜伏性原病毒上调病毒表达，抑制HIV诱导的细胞病变效应，向下调节HIV受体，增加Th1细胞因子表达，降低Th2细胞因子表达，增加ERK磷酸化，诱导 恶性细胞凋亡，诱导缓解，维持缓解作为化学治疗剂，以及降低可能伴随这种疾病的致病性疾病和机会性感染的症状。 提供了另外的组合物和方法，其使用佛波醇酯或衍生化合物与至少一种另外的试剂（例如HAART方案中使用的那些试剂，用于治疗由于HIV引起的机会性感染的治疗剂）或化学治疗剂组合产生更有效的治疗工具 针对哺乳动物受试者的致病性疾病。

公开(公告)号：US6063814A

公开(公告)日：2000-05-16

申请号：US837085

申请日：1997-04-14

申请人： Richard L. Chang ,  Zheng Tao Han

发明人： Richard L. Chang ,  Zheng Tao Han

IPC分类号： A61P35/00 ,  A61K31/216 ,  A61K31/22 ,  A61K31/23 ,  A61K31/235 ,  A61P35/02 ,  A61K31/21

CPC分类号： A61K31/235 ,  A61K31/216 ,  A61K31/22 ,  A61K31/23

摘要： Phorbol esters and particularly phorbol-12-myristate-13-acetate (TPA) are described as effective in treating patients with neoplastic diseases such as leukemia as well as in increasing the white blood cell count.

摘要翻译： 描述了佛波醇酯，特别是佛波醇-12-肉豆蔻酸-13-乙酸酯（TPA）在治疗患有白血病等肿瘤性疾病的患者中以及增加白细胞计数。