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公开(公告)号:US20160083435A9
公开(公告)日:2016-03-24
申请号:US13864658
申请日:2013-04-17
发明人: Robert M. Lohse , Patrick F. M. Meeus , Jason J. Millership , Zhichang Xu , Richard Thomas Marconi , Christopher G. Earnhart
IPC分类号: C07K14/20
CPC分类号: C07K14/20 , A61K39/0225 , A61K2039/552 , A61K2039/55505 , A61K2039/70 , C07K2319/00
摘要: The instant invention provides an immunogenic composition comprising an antigenic fragment of OspA protein of Borrelia burgdorferi and a chimeric protein containing antigenic fragments of different phylotypes of OspC protein of Borrelia burgdorferi. Vaccines incorporating the immunogenic composition of the invention, as well as methods of preventing Lyme disease in dogs and/or protecting dogs from Lyme disease using the vaccines are also provided.
摘要翻译: 本发明提供了一种免疫原性组合物,其包含布氏疏螺旋体的OspA蛋白的抗原性片段和含有不同的布氏疏螺旋体OspC蛋白的不同致病型的抗原片段的嵌合蛋白质。 还提供了掺入本发明的免疫原性组合物的疫苗,以及使用疫苗在狗和/或使用莱姆病保护狗来预防莱姆病的方法。
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公开(公告)号:US09562079B2
公开(公告)日:2017-02-07
申请号:US13864658
申请日:2013-04-17
发明人: Robert M. Lohse , Patrick F. M. Meeus , Jason J. Millership , Zhichang Xu , Richard Thomas Marconi , Christopher G. Earnhart
CPC分类号: C07K14/20 , A61K39/0225 , A61K2039/552 , A61K2039/55505 , A61K2039/70 , C07K2319/00
摘要: The instant invention provides an immunogenic composition comprising an antigenic fragment of OspA protein of Borrelia burgdorferi and a chimeric protein containing antigenic fragments of different phylotypes of OspC protein of Borrelia burgdorferi. Vaccines incorporating the immunogenic composition of the invention, as well as methods of preventing Lyme disease in dogs and/or protecting dogs from Lyme disease using the vaccines are also provided.
摘要翻译: 本发明提供了一种免疫原性组合物,其包含布氏疏螺旋体的OspA蛋白的抗原性片段和含有不同的布氏疏螺旋体OspC蛋白的不同致病型的抗原片段的嵌合蛋白质。 还提供了掺入本发明的免疫原性组合物的疫苗,以及使用疫苗在狗和/或使用莱姆病保护狗来预防莱姆病的方法。
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