公开(公告)号：US07006927B2

公开(公告)日：2006-02-28

申请号：US10086839

申请日：2002-02-28

申请人： Zohar Yakhini ,  Cynthia Y. Enderwick ,  Glenda C. Delenstarr ,  Paul K. Wolber ,  Nicholas M. Sampas ,  Herbert F. Cattell ,  Scott D. Connell

发明人： Zohar Yakhini ,  Cynthia Y. Enderwick ,  Glenda C. Delenstarr ,  Paul K. Wolber ,  Nicholas M. Sampas ,  Herbert F. Cattell ,  Scott D. Connell

IPC分类号： G06F11/32

CPC分类号： G06T7/73 ,  G06T2207/30072

摘要： A method and system for extracting data signals from a scanned image resulting from optical, radiometric, or other types of analysis of a molecular array. The positions of corner features are first located. Then, an initial feature coordinate grid is determined from the positions of the corner features. A refined feature coordinate grid is then calculated based on the positions of strong features, and is used to identify the positions of weak features and the positions of the local background regions surrounding all features. Finally, signal intensity values are extracted from the features and their respective local background regions in the scanned image, and background-subtracted signal intensity values, background-subtracted and normalized signal intensity ratios, and variability information and confidence intervals are determined based on the extracted values.

公开(公告)号：US06591196B1

公开(公告)日：2003-07-08

申请号：US09589046

申请日：2000-06-06

申请人： Zohar Yakhini ,  Cynthia Y. Enderwick ,  Glenda C. Delenstarr ,  Paul K. Wolber ,  Nicholas M. Sampas

发明人： Zohar Yakhini ,  Cynthia Y. Enderwick ,  Glenda C. Delenstarr ,  Paul K. Wolber ,  Nicholas M. Sampas

IPC分类号： G01J102

CPC分类号： G06K9/3275 ,  G06T7/73 ,  G06T2207/30072

摘要： A method and system for extracting data signals from a scanned image resulting from optical, radiometric, or other types of analysis of a molecular array. The positions of corner features are first located. Then, an initial feature coordinate grid is determined from the positions of the corner features. A refined feature coordinate grid is then calculated based on the positions of strong features, and is used to identify the positions of weak features and the positions of the local background regions surrounding all features. Finally, signal intensity values are extracted from the features and their respective local background regions in the scanned image, and background-subtracted signal intensity values, background-subtracted and normalized signal intensity ratios, and variability information and confidence intervals are determined based on the extracted values.

公开(公告)号：US07330606B2

公开(公告)日：2008-02-12

申请号：US10894943

申请日：2004-07-19

申请人： Zohar H. Yakhini ,  Cynthia Y. Enderwick ,  Glenda C. Delenstarr ,  Paul K. Wolber ,  Nicholas M. Sampas

发明人： Zohar H. Yakhini ,  Cynthia Y. Enderwick ,  Glenda C. Delenstarr ,  Paul K. Wolber ,  Nicholas M. Sampas

IPC分类号： G06K9/34

CPC分类号： G06K9/00 ,  G06K2209/07 ,  G06T7/73 ,  G06T2207/20068 ,  G06T2207/30072

摘要： A method for evaluating an orientation of a molecular array having features arranged in a pattern. An image of the molecular array is obtained by scanning the molecular array to determine data signals emanating from discrete positions on a surface of the molecular array. An actual result of a function on pixels of the image which pixels lie in a second pattern, is calculated. This actual result is compared with an expected result which would be obtained if the second pattern had a predetermined orientation on the array. Array orientation can then be evaluated based on the result.

摘要翻译： 一种用于评估具有以图案排列的特征的分子阵列的取向的方法。 通过扫描分子阵列以确定从分子阵列的表面上的离散位置发出的数据信号来获得分子阵列的图像。 计算像素处于第二图案的图像的像素的函数的实际结果。 将该实际结果与如果第二图案在阵列上具有预定取向将获得的预期结果进行比较。 然后可以基于结果来评估阵列取向。

公开(公告)号：US06768820B1

公开(公告)日：2004-07-27

申请号：US09659415

申请日：2000-09-11

申请人： Zohar H. Yakhini ,  Cynthia Y. Enderwick ,  Glenda C. Delenstarr ,  Paul K. Wolber ,  Nicholas M. Sampas

发明人： Zohar H. Yakhini ,  Cynthia Y. Enderwick ,  Glenda C. Delenstarr ,  Paul K. Wolber ,  Nicholas M. Sampas

IPC分类号： G06K936

CPC分类号： G06K9/3275 ,  G06T7/73 ,  G06T2207/30072

摘要： A method for evaluating an orientation of a molecular array having features arranged in a pattern. An image of the molecular array is obtained by scanning the molecular array to determine data signals emanating from discrete positions on a surface of the molecular array. An actual result of a function on pixels of the image which pixels lie in a second pattern, is calculated. This actual result is compared with an expected result which would be obtained if the second pattern had a predetermined orientation on the array. Array orientation can then be evaluated based on the result.

摘要翻译： 一种用于评估具有以图案排列的特征的分子阵列的取向的方法。 通过扫描分子阵列以确定从分子阵列的表面上的离散位置发出的数据信号来获得分子阵列的图像。 计算像素处于第二图案的图像的像素的函数的实际结果。 将该实际结果与如果第二图案在阵列上具有预定取向将获得的预期结果进行比较。 然后可以基于结果来评估阵列取向。