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公开(公告)号:US5374771A
公开(公告)日:1994-12-20
申请号:US67815
申请日:1993-05-27
申请人: Zoltan Konyari , Vilmos Keri , Antal Kovacs , Sandor Horkay , Laszlo Eszenyi , Janos Erdelyi , Ilona Himesi , Gyorgy Toth , Janos Balint , SzilaJudit , Ferenc Vinczi , Csaba Szabo , Nelli Sas
发明人: Zoltan Konyari , Vilmos Keri , Antal Kovacs , Sandor Horkay , Laszlo Eszenyi , Janos Erdelyi , Ilona Himesi , Gyorgy Toth , Janos Balint , SzilaJudit , Ferenc Vinczi , Csaba Szabo , Nelli Sas
IPC分类号: C07B63/00 , C07C239/18 , C07C259/06 , C07C303/32
CPC分类号: C07C239/18
摘要: A process for the preparation of high-purity deferoxamine salts from filtered fermentation liquors containing deferoxamine B as active ingredient by the adsorption of the active ingredient onto an ion exchange resin and the subsequent dissolution and purification thereof, which comprises carrying out the separation of the deferoxamine salt subsequent to the concentration of the eluate by salting out from an aqueous solution or from a mixture of water and an organic solvent and purifying it by repeated salting out and/or by methods known per se, and optionallya) preparing the methanesulfonate salt by known methods, orb) passing the aqueous solution of the deferoxamine salt trough an ion exchange resin containing methanesulfonate anions as counter ions and recovering the methanesulfonate salt from the effluent, preferably by lyophilization.
摘要翻译: 一种由含有去铁胺B作为活性成分的过滤发酵液制备高纯度去铁胺盐的方法,其通过将活性成分吸附到离子交换树脂上并随后的溶出和纯化,其包括进行去铁胺 通过从水溶液或水和有机溶剂的混合物中盐析而使洗脱液浓缩,然后通过重复盐析和/或通过本身已知的方法纯化洗脱液,并任选地,a)通过以下步骤制备甲磺酸盐: 或b)使脱铁胺盐水溶液通过含有甲磺酸根阴离子的离子交换树脂作为反离子,并优选通过冷冻干燥从流出物中回收甲磺酸盐。