专利检索 ap:("h. Lee Moffitt Cancer Center AND Research Institute, Inc.") AND inv:"Genyuan Zhu" 第 1 页

1.

发明申请
BIOENGINEERING TERTIARY LYMPHOID STRUCTURES USING CHITOSAN-BASED HYDROGELS 有权

公开(公告)号：US20210220441A1

公开(公告)日：2021-07-22

申请号：US17052973

申请日：2019-05-08

申请人： h. Lee Moffitt Cancer Center and Research Institute, Inc.

发明人： James Mulé , Rana Falahat , Genyuan Zhu

IPC分类号： A61K38/19 , A61K9/00 , A61K35/26 , A61K47/36

摘要： As disclosed herein, stromal cells are important for the recruitment and organization of lymphocytes in TLSs. Therefore, disclosed herein are composition and methods for bioengineering TLSs in animals, such as mice. These compositions involve chemokine-releasing microparticles or cells that can be implanted into the animals. Therefore, disclosed herein are chitosan hydrogels with chemokine releasing microparticles or cells.