公开(公告)号：US11253488B2

公开(公告)日：2022-02-22

申请号：US16114939

申请日：2018-08-28

申请人： pHase Pharmaceuticals LLC

发明人： G. Lynn Howard ,  Nicholas J. Farina ,  Edward J. Walters ,  Christopher Howard

IPC分类号： A61K31/137 ,  A61K9/00 ,  A61K9/20 ,  A61P3/08 ,  A61K47/26 ,  A61K47/38 ,  A61P37/08 ,  A61K47/12

摘要： The present disclosure provides sublingual epinephrine tablets and methods of treating anaphylaxis, methods for concomitant therapy during a cardiac event, treating hypoglycemia, and prophylaxis for immunotherapy, using sublingual epinephrine tablets.

公开(公告)号：US20230225994A1

公开(公告)日：2023-07-20

申请号：US18186918

申请日：2023-03-20

申请人： pHase Pharmaceuticals LLC

发明人： G. Lynn Howard ,  Nicholas J. Farina ,  Christopher Howard ,  Edward J. Walters

IPC分类号： A61K31/137 ,  A61K9/00 ,  A61K9/20 ,  A61P3/08 ,  A61K47/26 ,  A61K47/38 ,  A61P37/08 ,  A61K47/12

CPC分类号： A61K31/137 ,  A61K9/006 ,  A61K9/2018 ,  A61K9/2054 ,  A61P3/08 ,  A61K47/26 ,  A61K47/38 ,  A61P37/08 ,  A61K47/12

摘要： The present disclosure provides epinephrine formulations and methods of treating anaphylaxis, methods for concomitant therapy during a cardiac event, methods for treating hypoglycemia, and a prophylactic method for immunotherapy, using the epinephrine formulations disclosed herein. The epinephrine formulations of the present disclosed are formulated for delivery via the oral mucosa. Epinephrine formulations of the present disclosure may further comprise citric acid to improve delivery of epinephrine through the oral mucosa. The epinephrine formulations of the present disclosure induce a robust, global sympathetic response in a subject that is disproportionate to the serum epinephrine concentration in the subject.

公开(公告)号：US20220133654A1

公开(公告)日：2022-05-05

申请号：US17575489

申请日：2022-01-13

申请人： pHase Pharmaceuticals LLC

发明人： G. Lynn Howard ,  Nicholas J. Farina ,  Edward J. Walters ,  Christopher Howard

IPC分类号： A61K31/137 ,  A61K9/00 ,  A61K9/20 ,  A61P3/08 ,  A61K47/26 ,  A61K47/38 ,  A61P37/08 ,  A61K47/12

摘要： The present disclosure provides sublingual epinephrine tablets and methods of treating anaphylaxis, methods for concomitant therapy during a cardiac event, treating hypoglycemia, and prophylaxis for immunotherapy, using sublingual epinephrine tablets.

公开(公告)号：US12042472B2

公开(公告)日：2024-07-23

申请号：US17575489

申请日：2022-01-13

申请人： pHase Pharmaceuticals LLC

发明人： G. Lynn Howard ,  Nicholas J. Farina ,  Edward J. Walters ,  Christopher Howard

IPC分类号： A61K31/137 ,  A61K9/00 ,  A61K9/20 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  A61P3/08 ,  A61P37/08

CPC分类号： A61K31/137 ,  A61K9/006 ,  A61K9/2018 ,  A61K9/2054 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  A61P3/08 ,  A61P37/08

摘要： The present disclosure provides sublingual epinephrine tablets and methods of treating anaphylaxis, methods for concomitant therapy during a cardiac event, treating hypoglycemia, and prophylaxis for immunotherapy, using sublingual epinephrine tablets.

公开(公告)号：US20190070131A1

公开(公告)日：2019-03-07

申请号：US16114939

申请日：2018-08-28

申请人： pHase Pharmaceuticals LLC

发明人： G. Lynn Howard ,  Nicholas J. Farina ,  Edward J. Walters ,  Christopher Howard

IPC分类号： A61K31/137 ,  A61K9/00 ,  A61K9/20 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  A61P37/08 ,  A61P3/08

摘要： The present disclosure provides sublingual epinephrine tablets and methods of treating anaphylaxis, methods for concomitant therapy during a cardiac event, treating hypoglycemia, and prophylaxis for immunotherapy, using sublingual epinephrine tablets.