公开(公告)号：US4824937A

公开(公告)日：1989-04-25

申请号：US50208

申请日：1987-05-14

申请人： Romano Deghenghi ,  Hans U. Immer

发明人： Romano Deghenghi ,  Hans U. Immer

IPC分类号： C07K14/575 ,  A61K38/00 ,  A61P9/08 ,  A61P9/12 ,  C07K14/00 ,  C07K14/58 ,  C07K7/10

CPC分类号： C07K14/582 ,  A61K38/00

摘要： Synthetic natriuretic peptides (SNP) composed of 23 amino acid residues of which residues 2-23 have the natural L-configuration while the amino-terminal residue is derived from an unnatural amino acid having the D-configuration. The compounds possess diuretic, natriuretic, vasorelaxant, smooth muscle relaxant, hypotensive, and anti-hypertensive activities, and a process for their preparation is also disclosed, together with pharmaceutical preparations thereof and with their use in the practice of medicine. Salts of said synthetic natriuretic peptides with pharmaceutically acceptable acids are also disclosed.

摘要翻译： 由23个氨基酸残基组成的合成利钠肽（SNP），其中残基2-23具有天然的L-构型，而氨基末端残基源自具有D-构型的非天然氨基酸。 该化合物具有利尿，利尿钠，血管舒张，平滑肌松弛剂，降血压和抗高血压活性，并且还公开了其制备方法及其药物制剂及其在药物实践中的用途。 还公开了所述合成利钠肽与药学上可接受的酸的盐。