公开(公告)号：US20230174511A1

公开(公告)日：2023-06-08

申请号：US17883202

申请日：2022-08-08

Applicant: Viracta Therapeutics, Inc. ,  Biogen MA Inc.

Inventor： Brian T. HOPKINS ,  Timothy R. CHAN ,  Tracy J. JENKINS ,  Patrick CONLON ,  Xiongwei CAI ,  Michael HUMORA ,  Xianglin SHI ,  Ross A. MILLER ,  Andrew THOMPSON

IPC: C07D401/14

CPC classification number: C07D401/14

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton’s tyrosine kinase and which exhibit desirable characteristics for the same.

公开(公告)号：US20190083404A1

公开(公告)日：2019-03-21

申请号：US15527539

申请日：2015-11-19

Applicant: BIOGEN MA INC.

Inventor： Shyam B. Karki ,  Peter Zawaneh ,  Cheuk-Yui Leung ,  Yiqing Lin

IPC: A61K9/20 ,  A61K31/225 ,  A61K45/06 ,  A61K9/28 ,  A61K9/48

Abstract: The present invention provides novel pharmaceutical compositions of dimethyl fumarate. The pharmaceutical compositions of the present invention are in the form of a tablet and comprise one or more extended release polymer matrix. Also provided are pharmaceutical compositions in the form of a capsule comprising one or more tablets of the present invention. Methods of using the pharmaceutical compositions of the present invention for treating multiple sclerosis are also included.

公开(公告)号：US12275728B2

公开(公告)日：2025-04-15

申请号：US18673619

申请日：2024-05-24

Applicant: BIOGEN MA INC.

Inventor： Nathan Genung ,  Kevin M. Guckian ,  Jeffrey Vessels ,  Lei Zhang ,  Ryan Gianatassio ,  Edward Yin Shiang Lin ,  Zhili Xin

IPC: C07D417/14 ,  A61P25/28 ,  C07D417/06

Abstract: Described herein are compounds represented by formulas (IA) or (IB) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of preparing and using the same. The variables R1, R3, R4, Y1, Y2, Ar, Z and n are as defined herein.

公开(公告)号：US20250090524A1

公开(公告)日：2025-03-20

申请号：US18709268

申请日：2022-11-11

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  BIn Ma ,  Jürgen Schulz ,  Marta Nevalainen ,  TeYu Chen ,  Robin J. Prince ,  Harold George Vandeveer ,  Issac Marx ,  Simone Sciaboba ,  Edward Yin Shiang Lin

IPC: A61K31/4985 ,  A61K31/437 ,  A61K31/55 ,  C07D471/04 ,  C07D487/04

Abstract: Provided are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein the variables in Formula (I) are as defined herein; and methods for their use and production.

公开(公告)号：US12240838B2

公开(公告)日：2025-03-04

申请号：US17610963

申请日：2020-05-15

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Robin Prince ,  Isaac Marx ,  Jürgen Schulz ,  Marta Nevalainen

IPC: C07D413/12 ,  C07D401/12 ,  C07D413/14 ,  C07D417/12

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US20250034590A1

公开(公告)日：2025-01-30

申请号：US18717244

申请日：2022-12-06

Applicant: Biogen MA Inc.

Inventor： Jenny Wang-Yuanzhen Shupe ,  Alexander Vaca

IPC: C12N15/86

Abstract: The present disclosure pertains to methods for transducing host cells with nucleic acids using an in-line complexer and systems comprising an in-line complexer for transducing host cells. The disclosed methods and systems can be used to produce recombinant adeno-associated virus (rAAV) particles. Also disclosed herein are compositions comprising rAAV particles obtained from the disclosed methods and systems, and uses of the same.

公开(公告)号：US20250034150A1

公开(公告)日：2025-01-30

申请号：US18709273

申请日：2022-11-10

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Jürgen Schulz ,  Marta Nevalainen ,  TeYu Chen ,  Robin Prince ,  Harold George Vandeveer ,  Isaac Marx ,  Simone Sciabola ,  Zain Yousaf

IPC: C07D487/04 ,  A61K31/437 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/55 ,  C07D471/04 ,  C07D519/00

Abstract: Provided are compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein the variables in Formula (I) are as defined herein; and methods for their use and production.

公开(公告)号：US20250020660A1

公开(公告)日：2025-01-16

申请号：US18426232

申请日：2024-01-29

Applicant: Biogen MA Inc.

Inventor： Meena Subramanyam ,  Lakshimi Amaravadi ,  Eric Wakshull ,  Frances Lynn ,  Michael Panzara ,  Robin McDaid Barbour ,  Julie Elizabeth Taylor

IPC: G01N33/68 ,  C07K16/28

Abstract: The invention relates to methods and products for the identification of a clinically significant immune response in subjects treated with a therapeutic protein. Aspects of the invention relate to methods and compositions for identifying a clinically significant immune response in patients treated with therapeutic amounts of a VLA4 binding antibody (e.g., natalizumab).

公开(公告)号：US20240425573A1

公开(公告)日：2024-12-26

申请号：US18707366

申请日：2022-11-02

Applicant: Biogen MA Inc.

Inventor： Laura Nisenbaum ,  Tianle Chen ,  Raj Rajagovindan

IPC: C07K16/18 ,  A61K39/00 ,  A61P25/28 ,  G01N33/68

Abstract: Provided are methods for treating Alzheimer's disease in a human subject in need thereof comprising administration of an anti-beta-amyloid antibody (e.g., aducanumab) to the subject.

公开(公告)号：US12162952B2

公开(公告)日：2024-12-10

申请号：US17050353

申请日：2019-04-25

Applicant: Biogen MA Inc. ,  Neurimmune AG

Inventor： Jan Grimm ,  Fabio Montrasio ,  Isin Dalkilic-Liddle ,  Mia Marie Rushe ,  Joseph Walter Arndt

IPC: C07K16/00 ,  A61K47/68 ,  A61K49/00 ,  A61K51/10 ,  C07K16/44 ,  G01N33/53

Abstract: Provided are novel dipeptide repeat (DPR) specific antibodies (e.g., human-derived antibodies) as well as synthetic variants and biotechnological derivatives thereof, capable of binding C9orf72 poly-glycine-alanine DPRs, as well as methods and uses related thereto. The antibody of the present invention can be used in pharmaceutical and diagnostic compositions for DPR protein-targeted immunotherapy and diagnostics.