-
公开(公告)号：US5273525A
公开(公告)日：1993-12-28
申请号：US929103
申请日：1992-08-13
申请人： Gunter A. Hofmann
发明人： Gunter A. Hofmann
CPC分类号： A61N1/327
摘要： An apparatus for implanting macromolecules such as genes, DNA or pharmaceuticals into a preselected tissue region such as a muscle or an organ of a patient. A modified syringe is provided for injecting a predetermined quantity of a fluid medium carrying the preselected macromolecules. A signal generator is connected to the syringe for generating a predetermined electric signal. The syringe includes a pair of electrodes which are connected to the signal generator for applying an electric field in the tissue region. The field has a predetermined strength and duration in order to make the walls of a plurality of cells in the tissue region transiently permeable to permit the macromolecules to enter said preselected cells without damaging said cells. This enhances the uptake of macromolecules and thus enhances the therapeutic effect achieved. Alternate embodiments having twin needles and a blade may be utilized.
摘要翻译： 用于将诸如基因，DNA或药物之类的大分子植入预选的组织区域例如患者的肌肉或器官的装置。 提供改进的注射器用于注射预定量的携带预选大分子的流体介质。 信号发生器连接到注射器以产生预定的电信号。 注射器包括连接到信号发生器的一对电极，用于在组织区域中施加电场。 该场具有预定的强度和持续时间，以便使组织区域中的多个细胞的壁瞬时渗透以允许大分子进入所述预选细胞而不损坏所述细胞。 这增强了大分子的吸收，从而增强了所获得的治疗效果。 可以使用具有双针和刀片的替代实施例。
-
2.发明授权
公开(公告)号：US5318514A
公开(公告)日：1994-06-07
申请号：US931061
申请日：1992-08-17
申请人： Gunter A. Hofmann
发明人： Gunter A. Hofmann
CPC分类号： A61N1/327 , A61N1/303 , A61M2037/0007
摘要： An apparatus for implanting macromolecules such as genes, DNA or pharmaceuticals into a preselected surface tissue region of of a patient. An applicator having a plurality of electrodes is provided for contacting a surface tissue region of a patient. A mechanism associated with the applicator delivers a predetermined quantity of a fluid medium carrying the preselected macromolecules. A signal generator is provided for generating a predetermined electric signal. The electrodes of the applicator are connected to the signal generator for applying an electric field in the surface tissue region. The field has a predetermined strength and duration in order to make the walls of a plurality of cells in the surface tissue region transiently permeable to permit the macromolecules to enter said preselected cells without damaging said cells. This enhances the uptake of macromolecules and thus enhances the therapeutic effect achieved.
摘要翻译： 用于将大分子如基因，DNA或药物植入患者的预选表面组织区域中的装置。 提供具有多个电极的施加器，用于接触患者的表面组织区域。 与施用器相关联的机构输送预定量的携带预选大分子的流体介质。 提供信号发生器用于产生预定的电信号。 施加器的电极连接到信号发生器，用于在表面组织区域中施加电场。 该场具有预定的强度和持续时间，以使得表面组织区域中的多个细胞的壁瞬时渗透以允许大分子进入所述预选细胞而不损坏所述细胞。 这增强了大分子的吸收，从而增强了所获得的治疗效果。
-
3.发明授权Electroporation method and apparatus for insertion of drugs and genes into endothelial cells 失效用于将药物和基因插入内皮细胞的电穿孔方法和装置
公开(公告)号：US5304120A
公开(公告)日：1994-04-19
申请号：US907322
申请日：1992-07-01
摘要： A catheter device is inserted into a selected blood vessel of a patient and advanced to a preselected location within the blood vessel where the endothelial cells on the inner wall of the vessel are to be treated. Once in place, the catheter device is expanded so that a plurality of axially extending, circumferentially spaced electrodes carried thereby are in contact with the inner wall of the blood vessel. A fluid medium is then infused into the blood vessel adjacent the electrodes via a conventional pump. A power pack connected to the electrodes is energized to apply a predetermined electric signal to the electrodes. This subjects the endothelial cells to electric fields of predetermined amplitude and duration in order to make the walls of the endothelial cells transiently permeable to permit therapeutic genes or drugs carried by the fluid medium to enter the endothelial cells without killing them.
摘要翻译： 将导管装置插入到患者的所选择的血管中并且前进到血管内预先选定的位置，其中血管内壁上的内皮细胞将被处理。 一旦就位，导管装置被扩张，使得由其携带的多个轴向延伸的周向隔开的电极与血管的内壁接触。 然后通过常规泵将流体介质输入到与电极相邻的血管中。 连接到电极的电源组通电以向电极施加预定的电信号。 这将使内皮细胞受到预定幅度和持续时间的电场，以使内皮细胞的壁瞬时渗透以允许治疗基因或由流体介质携带的药物进入内皮细胞而不杀死它们。
-
-
搜索结果
3 条记录 (耗时 0.01 秒)
